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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei199 – 1991NADUniRule annotation
Binding sitei222 – 2221SubstrateUniRule annotation
Metal bindingi244 – 2441ZincUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Metal bindingi247 – 2471ZincUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Active sitei298 – 2981Proton acceptorUniRule annotation
Active sitei299 – 2991Proton acceptorUniRule annotation
Binding sitei299 – 2991SubstrateUniRule annotation
Metal bindingi331 – 3311ZincUniRule annotation
Binding sitei331 – 3311SubstrateUniRule annotation
Binding sitei384 – 3841SubstrateUniRule annotation
Metal bindingi389 – 3891ZincUniRule annotation
Binding sitei389 – 3891SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSISL419942:GHVO-1343-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:YN1551_1297Imported
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)Imported
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006818 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi419942.YN1551_1297.

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NGY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISYSLPNER PNDFSRVIPV VRDIIESVKA RGDNALYQLT EKLDKVKINN
60 70 80 90 100
IKVSEEELKT QASKLDPKVK QAIDVAYEQL KAFHEMLVPP NIGGGYQGIS
110 120 130 140 150
FGVVWRSIEK IGIYVPSGKY SYPSTLLMAG IPAKVAKVKE IYVASPPNQE
160 170 180 190 200
GSVNPALAYV AIKLGVNDVY KVGGAQAIAA LAYGTESVRK VYKIVGPGNV
210 220 230 240 250
YVQAAKFLVS NVVGIDGIEG PTELVIIADE TAKAEHVVLD MKAQAEHGPD
260 270 280 290 300
TYIVLLSNDD ELLKKVEEKI MDDKKIYYII KTKNIDEAIE IANKIAPEHL
310 320 330 340 350
SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWARIRG
360 370 380 390
GVTVYDFIKP TMYANVRDIN KQLLEASISL ANYEGFVIHG KSIGVRYE
Length:398
Mass (Da):43,606
Last modified:June 16, 2009 - v1
Checksum:i5642CBB806FA93FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001404 Genomic DNA. Translation: ACP48392.1.
RefSeqiWP_012717403.1. NC_012623.1.
YP_002840314.1. NC_012623.1.

Genome annotation databases

EnsemblBacteriaiACP48392; ACP48392; YN1551_1297.
GeneIDi7810082.
KEGGisin:YN1551_1297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001404 Genomic DNA. Translation: ACP48392.1.
RefSeqiWP_012717403.1. NC_012623.1.
YP_002840314.1. NC_012623.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419942.YN1551_1297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP48392; ACP48392; YN1551_1297.
GeneIDi7810082.
KEGGisin:YN1551_1297.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciSISL419942:GHVO-1343-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.N.15.51 / Yellowstone #2Imported.

Entry informationi

Entry nameiC3NGY2_SULIN
AccessioniPrimary (citable) accession number: C3NGY2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 29, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.