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C3NGY2

- C3NGY2_SULIN

UniProt

C3NGY2 - C3NGY2_SULIN

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Protein
Histidinol dehydrogenase
Gene
hisD, YN1551_1297
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NAD By similarityUniRule annotation
Binding sitei176 – 1761NAD By similarityUniRule annotation
Binding sitei199 – 1991NAD By similarityUniRule annotation
Binding sitei222 – 2221Substrate By similarityUniRule annotation
Metal bindingi244 – 2441Zinc By similarityUniRule annotation
Binding sitei244 – 2441Substrate By similarityUniRule annotation
Metal bindingi247 – 2471Zinc By similarityUniRule annotation
Binding sitei247 – 2471Substrate By similarityUniRule annotation
Active sitei298 – 2981Proton acceptor By similarityUniRule annotation
Active sitei299 – 2991Proton acceptor By similarityUniRule annotation
Binding sitei299 – 2991Substrate By similarityUniRule annotation
Metal bindingi331 – 3311Zinc By similarityUniRule annotation
Binding sitei331 – 3311Substrate By similarityUniRule annotation
Binding sitei384 – 3841Substrate By similarityUniRule annotation
Metal bindingi389 – 3891Zinc By similarityUniRule annotation
Binding sitei389 – 3891Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSISL419942:GHVO-1343-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:YN1551_1297Imported
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)Imported
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006818: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi419942.YN1551_1297.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NGY2-1 [UniParc]FASTAAdd to Basket

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MISYSLPNER PNDFSRVIPV VRDIIESVKA RGDNALYQLT EKLDKVKINN    50
IKVSEEELKT QASKLDPKVK QAIDVAYEQL KAFHEMLVPP NIGGGYQGIS 100
FGVVWRSIEK IGIYVPSGKY SYPSTLLMAG IPAKVAKVKE IYVASPPNQE 150
GSVNPALAYV AIKLGVNDVY KVGGAQAIAA LAYGTESVRK VYKIVGPGNV 200
YVQAAKFLVS NVVGIDGIEG PTELVIIADE TAKAEHVVLD MKAQAEHGPD 250
TYIVLLSNDD ELLKKVEEKI MDDKKIYYII KTKNIDEAIE IANKIAPEHL 300
SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWARIRG 350
GVTVYDFIKP TMYANVRDIN KQLLEASISL ANYEGFVIHG KSIGVRYE 398
Length:398
Mass (Da):43,606
Last modified:June 16, 2009 - v1
Checksum:i5642CBB806FA93FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP48392.1.
RefSeqiYP_002840314.1. NC_012623.1.

Genome annotation databases

EnsemblBacteriaiACP48392; ACP48392; YN1551_1297.
GeneIDi7810082.
KEGGisin:YN1551_1297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP48392.1 .
RefSeqi YP_002840314.1. NC_012623.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419942.YN1551_1297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP48392 ; ACP48392 ; YN1551_1297 .
GeneIDi 7810082.
KEGGi sin:YN1551_1297.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SISL419942:GHVO-1343-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.N.15.51 / Yellowstone #2.

Entry informationi

Entry nameiC3NGY2_SULIN
AccessioniPrimary (citable) accession number: C3NGY2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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