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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. no protein annotated in this organism
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei199NADUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Metal bindingi244ZincUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Metal bindingi247ZincUniRule annotation1
Binding sitei247SubstrateUniRule annotation1
Active sitei298Proton acceptorUniRule annotation1
Active sitei299Proton acceptorUniRule annotation1
Binding sitei299SubstrateUniRule annotation1
Metal bindingi331ZincUniRule annotation1
Binding sitei331SubstrateUniRule annotation1
Binding sitei384SubstrateUniRule annotation1
Metal bindingi389ZincUniRule annotation1
Binding sitei389SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSISL419942:G1GV0-1282-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:YN1551_1297Imported
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)Imported
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000006818 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG093Z04GH

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

C3NGY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISYSLPNER PNDFSRVIPV VRDIIESVKA RGDNALYQLT EKLDKVKINN
60 70 80 90 100
IKVSEEELKT QASKLDPKVK QAIDVAYEQL KAFHEMLVPP NIGGGYQGIS
110 120 130 140 150
FGVVWRSIEK IGIYVPSGKY SYPSTLLMAG IPAKVAKVKE IYVASPPNQE
160 170 180 190 200
GSVNPALAYV AIKLGVNDVY KVGGAQAIAA LAYGTESVRK VYKIVGPGNV
210 220 230 240 250
YVQAAKFLVS NVVGIDGIEG PTELVIIADE TAKAEHVVLD MKAQAEHGPD
260 270 280 290 300
TYIVLLSNDD ELLKKVEEKI MDDKKIYYII KTKNIDEAIE IANKIAPEHL
310 320 330 340 350
SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWARIRG
360 370 380 390
GVTVYDFIKP TMYANVRDIN KQLLEASISL ANYEGFVIHG KSIGVRYE
Length:398
Mass (Da):43,606
Last modified:June 16, 2009 - v1
Checksum:i5642CBB806FA93FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001404 Genomic DNA Translation: ACP48392.1
RefSeqiWP_012717403.1, NC_012623.1

Genome annotation databases

EnsemblBacteriaiACP48392; ACP48392; YN1551_1297
GeneIDi7810082
KEGGisin:YN1551_1297

Similar proteinsi

Entry informationi

Entry nameiC3NGY2_SULIN
AccessioniPrimary (citable) accession number: C3NGY2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health