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C3NF69

- GSA_SULIN

UniProt

C3NF69 - GSA_SULIN

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, YN1551_0843
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSISL419942:GHVO-867-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:YN1551_0843
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006818: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000382418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi419942.YN1551_0843.

Structurei

3D structure databases

ProteinModelPortaliC3NF69.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHGHANAF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NF69-1 [UniParc]FASTAAdd to Basket

« Hide

MDKGRCTILN SEELWAQARQ LFAGGVNSPV RAAVKPFPFY VERGKGAYIY    50
TVEGNKFIDY VLGYGPLILG HSPESVKRKI IEQLEKGWLF GTPSKLEIEL 100
AKKISSHIPS AQKIRFVNSG TEATMAAIRL ARGYSKRSKI LKFSGNYHGA 150
HDYTLVEAGS AATEYNVTTS DGIPMEIMKT VEICEFNDLD CVDKKLRNED 200
IAAALLEPIM GNAGVILPEK GFLSGLRELT KSYNSLLIFD EVITGFRIDI 250
GGAQSYYQIY PDITTLGKII GGGFPIGAVA GKAEIIDNFT PAGRVFNAGT 300
FNANPISMIA GIATIEELEK EYPYNIANKA SKTLVEELER LLKIKHTINH 350
IGSMFQVFFG IDKVRNYSDA KRANKEYYIK FHERLLKERV FIPPSQYETI 400
FTSAAHEDDV VNDTIDKLAK VIGELS 426
Length:426
Mass (Da):47,261
Last modified:June 16, 2009 - v1
Checksum:i82BFEC7AB6396FA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP47965.1.
RefSeqiYP_002839887.1. NC_012623.1.

Genome annotation databases

EnsemblBacteriaiACP47965; ACP47965; YN1551_0843.
GeneIDi7809525.
KEGGisin:YN1551_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP47965.1 .
RefSeqi YP_002839887.1. NC_012623.1.

3D structure databases

ProteinModelPortali C3NF69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419942.YN1551_0843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP47965 ; ACP47965 ; YN1551_0843 .
GeneIDi 7809525.
KEGGi sin:YN1551_0843.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HGHANAF.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci SISL419942:GHVO-867-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.N.15.51 / Yellowstone #2.

Entry informationi

Entry nameiGSA_SULIN
AccessioniPrimary (citable) accession number: C3NF69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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