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C3NE39

- OGG1_SULIY

UniProt

C3NE39 - OGG1_SULIY

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, YG5714_1311
Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciSISL439386:GHF0-1355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:YG5714_1311
OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Taxonomic identifieri439386 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000002308: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_1000204474Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439386.YG5714_1311.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

C3NE39-1 [UniParc]FASTAAdd to Basket

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MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS    50
AYQALNCLGD KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL 100
KEEITPLADS DQQLAREKLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI 150
DFMRRIGAIG ETNVKHLSKS RYISLESVLK SIALNLNISV GILDLFIWYK 200
ETNTIVK 207
Length:207
Mass (Da):24,071
Last modified:June 16, 2009 - v1
Checksum:iD56EDB4A5C5A4562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP45578.1.
RefSeqiYP_002837500.1. NC_012622.1.

Genome annotation databases

EnsemblBacteriaiACP45578; ACP45578; YG5714_1311.
GeneIDi7807541.
KEGGisiy:YG5714_1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP45578.1 .
RefSeqi YP_002837500.1. NC_012622.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439386.YG5714_1311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP45578 ; ACP45578 ; YG5714_1311 .
GeneIDi 7807541.
KEGGi siy:YG5714_1311.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.

Enzyme and pathway databases

BioCyci SISL439386:GHF0-1355-MONOMER.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.G.57.14 / Yellowstone #1.

Entry informationi

Entry nameiOGG1_SULIY
AccessioniPrimary (citable) accession number: C3NE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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