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C3NE39

- OGG1_SULIY

UniProt

C3NE39 - OGG1_SULIY

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281UniRule annotation

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciSISL439386:GHF0-1355-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyaseUniRule annotation
    Including the following 2 domains:
    8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
    Short name:
    AP lyaseUniRule annotation
    Gene namesi
    Name:oggUniRule annotation
    Ordered Locus Names:YG5714_1311
    OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
    Taxonomic identifieri439386 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000002308: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_1000204474Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439386.YG5714_1311.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1059.
    HOGENOMiHOG000224507.
    KOiK03653.
    OMAiLDLYLWY.

    Family and domain databases

    Gene3Di1.10.340.30. 1 hit.
    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PfamiPF00730. HhH-GPD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3NE39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS    50
    AYQALNCLGD KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL 100
    KEEITPLADS DQQLAREKLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI 150
    DFMRRIGAIG ETNVKHLSKS RYISLESVLK SIALNLNISV GILDLFIWYK 200
    ETNTIVK 207
    Length:207
    Mass (Da):24,071
    Last modified:June 16, 2009 - v1
    Checksum:iD56EDB4A5C5A4562
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001403 Genomic DNA. Translation: ACP45578.1.
    RefSeqiYP_002837500.1. NC_012622.1.

    Genome annotation databases

    EnsemblBacteriaiACP45578; ACP45578; YG5714_1311.
    GeneIDi7807541.
    KEGGisiy:YG5714_1311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001403 Genomic DNA. Translation: ACP45578.1 .
    RefSeqi YP_002837500.1. NC_012622.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439386.YG5714_1311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP45578 ; ACP45578 ; YG5714_1311 .
    GeneIDi 7807541.
    KEGGi siy:YG5714_1311.

    Phylogenomic databases

    eggNOGi COG1059.
    HOGENOMi HOG000224507.
    KOi K03653.
    OMAi LDLYLWY.

    Enzyme and pathway databases

    BioCyci SISL439386:GHF0-1355-MONOMER.

    Family and domain databases

    Gene3Di 1.10.340.30. 1 hit.
    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    Pfami PF00730. HhH-GPD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y.G.57.14 / Yellowstone #1.

    Entry informationi

    Entry nameiOGG1_SULIY
    AccessioniPrimary (citable) accession number: C3NE39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3