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C3NE25 (GCSPA_SULIY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:YG5714_1297
OrganismSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) [Complete proteome] [HAMAP]
Taxonomic identifier439386 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000212669

Sequences

Sequence LengthMass (Da)Tools
C3NE25 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 917F4ADDA16DA026

FASTA45551,306
        10         20         30         40         50         60 
MYKHPWLPNL DLIDEMLKEI GVNSLDELFN DIPAEIKINR LLNVAKGKPL SEYEIEKEIN 

        70         80         90        100        110        120 
EKVKKNVELQ APPFIGAGIC PHYIPNVVKF IIGRSEFYTS YTPYQPEISQ GLLQALFEYQ 

       130        140        150        160        170        180 
SLMAELLDMD VVNASMYDWG SALAEAVLMA NRINGKKTVL VPENANPFHK EVVRTWIGGK 

       190        200        210        220        230        240 
GIKIEEVKYD KNSGELDLED LEKKSNIDDI SAIYIQQPNF FGIFESNIEH VIDVAKHKRA 

       250        260        270        280        290        300 
LSIVGVNPLS LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGVFAVRW DMSLVRQMPG 

       310        320        330        340        350        360 
RIVGITKDTN GKMGFTLILQ TREQFIKREK ATSNITTNEA LLAIANAVYL SLLGKEGMRE 

       370        380        390        400        410        420 
LTEEIYFRSH YAAKKLTEID NVSMPFRSDF FEEFAIRFPI EYDKISNKLK ERKLQGGLKL 

       430        440        450 
SDYTSLFCVT EVHDKKSIDL LVSTIQEMIN GVETS 

« Hide

References

[1]"Biogeography of the Sulfolobus islandicus pan-genome."
Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.
Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y.G.57.14 / Yellowstone #1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001403 Genomic DNA. Translation: ACP45564.1.
RefSeqYP_002837486.1. NC_012622.1.

3D structure databases

ProteinModelPortalC3NE25.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439386.YG5714_1297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP45564; ACP45564; YG5714_1297.
GeneID7807526.
KEGGsiy:YG5714_1297.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAGLEVANC.

Enzyme and pathway databases

BioCycSISL439386:GHF0-1340-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_SULIY
AccessionPrimary (citable) accession number: C3NE25
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families