C3ND58 (C3ND58_SULIY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193
Ordered Locus Names:	YG5714_2969

Organism

Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) [Complete proteome] [HAMAP]

Taxonomic identifier

439386 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. RuleBase RU004252 HAMAP MF_00193
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 RuleBase RU003811 NAD HAMAP MF_00193 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 RuleBase RU003811 EMBL ACP47188.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	67	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	C3ND58 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 392D4B46A80A3435	FASTA	304	34,655
	10 20 30 40 50 60 MAFSKFSSFR WYYTLNICST NILIMVMHEY IRKSLTIDCE AVTNYIVERI REYLEFSNKK 70 80 90 100 110 120 GGVIGVSGGA DSAVTATLLA KATDNFFILL MPSSSTPKID LEDSFEMIKF LNAQNKYKLI 130 140 150 160 170 180 NIDEIVSLFS NKIETNNKYV IGNIKARVRM IILYAYAQML DYLVVGTGDK SELLLGYFTK 190 200 210 220 230 240 YGDGGVDVLP IGDLYKTQVR MLGKCLGLPE RIVTKPSSPA LWEGQTAEGE LGIDYETIDS 250 260 270 280 290 300 ILYLRFDEMR SEDEIVKMLG IPIDTIKKVD RLVKISQHKR LPPEIFRLSG RAINSDWRFP RRWA

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001403 Genomic DNA. Translation: ACP47188.1.
RefSeq	YP_002839110.1. NC_012622.1.
3D structure databases
ProteinModelPortal	C3ND58.
ModBase	Search...
Protein-protein interaction databases
STRING	C3ND58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7805662.
GenomeReviews	Gene locus YG5714_2969 in contig CP001403_GR.
KEGG	siy:YG5714_2969.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YDISARD.
ProtClustDB	PRK13980.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C3ND58_SULIY

Accession

Primary (citable) accession number: C3ND58

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)