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C3N866 (LYSK_SULIY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-lysine deacetylase

EC=3.5.1.-
Gene names
Name:lysK
Ordered Locus Names:YG5714_2101
OrganismSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) [Complete proteome] [HAMAP]
Taxonomic identifier439386 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-lysine + H2O = acetate + L-lysine. HAMAP-Rule MF_01120

Cofactor

Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP-Rule MF_01120

Glutathione By similarity. HAMAP-Rule MF_01120

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5. HAMAP-Rule MF_01120

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01120

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01120.

Sequence similarities

Belongs to the peptidase M20A family. LysK subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Acetyl-lysine deacetylase HAMAP-Rule MF_01120
PRO_1000213618

Sites

Active site701 By similarity
Active site1221Proton acceptor By similarity
Metal binding681Cobalt or zinc 1 By similarity
Metal binding921Cobalt or zinc 1 By similarity
Metal binding921Cobalt or zinc 2 By similarity
Metal binding1231Cobalt or zinc 2 By similarity
Metal binding1461Cobalt or zinc 1 By similarity
Metal binding3171Cobalt or zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3N866 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: BDE8A5BEEBA0BAF6

FASTA34638,769
        10         20         30         40         50         60 
MQQEKELVKQ KAKELLLDLL SIYTPSKNET NATKFFEKIS NEFNLKLEIL PDSNSFILGE 

        70         80         90        100        110        120 
GEILLASHVD TVPGYIEPKI ENEVIYGRGA VDAKGPLISM IIAAWLLNEK GIKVMVSGLA 

       130        140        150        160        170        180 
DEESTSIGAK ELTLKNFNFK HIIVGEPSNG TDIVVEYRGS IQLDIMCEST PEHSSSAKSN 

       190        200        210        220        230        240 
LIVDISKKII EVYKQPENYD KPSIVPTIIR AGESYNVTPA KLYLHFDVRY AINNKRDDLI 

       250        260        270        280        290        300 
NEIKDKFQEC GLKIVDETPP VKVSINNPVV KSLTRALLKQ NIKPRLVRKA GTSDMNILQK 

       310        320        330        340 
ITTSIATYGP GNSMLEHTNQ EKITLDEIYI GVKTYMLAIE ELWQKS 

« Hide

References

[1]"Biogeography of the Sulfolobus islandicus pan-genome."
Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.
Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y.G.57.14 / Yellowstone #1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001403 Genomic DNA. Translation: ACP46353.1.
RefSeqYP_002838275.1. NC_012622.1.

3D structure databases

ProteinModelPortalC3N866.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439386.YG5714_2101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP46353; ACP46353; YG5714_2101.
GeneID7807920.
KEGGsiy:YG5714_2101.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0624.
HOGENOMHOG000105331.
KOK05831.
OMAGDSDLDH.

Enzyme and pathway databases

BioCycSISL439386:GHF0-2186-MONOMER.
UniPathwayUPA00033; UER00039.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
HAMAPMF_01120. Acet_lys_deacetyl.
InterProIPR023556. Acetyl-lysine_deAcylase.
IPR001261. ArgE/DapE_CS.
IPR010175. DapE_lys_deAc.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMSSF55031. SSF55031. 1 hit.
TIGRFAMsTIGR01902. dapE-lys-deAc. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYSK_SULIY
AccessionPrimary (citable) accession number: C3N866
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways