C3N866 (LYSK_SULIY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-lysine deacetylase
EC=3.5.1.-

Gene names

Name:	lysK
Ordered Locus Names:	YG5714_2101

Organism

Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) [Complete proteome] [HAMAP]

Taxonomic identifier

439386 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus islandicus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-lysine + H2O = acetate + L-lysine. HAMAP-Rule MF_01120
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. Glutathione By similarity.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5. HAMAP-Rule MF_01120
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M20A family. LysK subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via aminoadipic acid Inferred from electronic annotation. Source: UniProtKB-UniPathway proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cobalt ion binding Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Inferred from electronic annotation. Source: HAMAP metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Acetyl-lysine deacetylase HAMAP-Rule MF_01120		PRO_1000213618
Sites
	Active site	70	1	By similarity
	Active site	122	1	Proton acceptor By similarity
	Metal binding	68	1	Cobalt or zinc 1 By similarity
	Metal binding	92	1	Cobalt or zinc 1 By similarity
	Metal binding	92	1	Cobalt or zinc 2 By similarity
	Metal binding	123	1	Cobalt or zinc 2 By similarity
	Metal binding	146	1	Cobalt or zinc 1 By similarity
	Metal binding	317	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3N866 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: BDE8A5BEEBA0BAF6	FASTA	346	38,769
	10 20 30 40 50 60 MQQEKELVKQ KAKELLLDLL SIYTPSKNET NATKFFEKIS NEFNLKLEIL PDSNSFILGE 70 80 90 100 110 120 GEILLASHVD TVPGYIEPKI ENEVIYGRGA VDAKGPLISM IIAAWLLNEK GIKVMVSGLA 130 140 150 160 170 180 DEESTSIGAK ELTLKNFNFK HIIVGEPSNG TDIVVEYRGS IQLDIMCEST PEHSSSAKSN 190 200 210 220 230 240 LIVDISKKII EVYKQPENYD KPSIVPTIIR AGESYNVTPA KLYLHFDVRY AINNKRDDLI 250 260 270 280 290 300 NEIKDKFQEC GLKIVDETPP VKVSINNPVV KSLTRALLKQ NIKPRLVRKA GTSDMNILQK 310 320 330 340 ITTSIATYGP GNSMLEHTNQ EKITLDEIYI GVKTYMLAIE ELWQKS

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Y.G.57.14 / Yellowstone #1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001403 Genomic DNA. Translation: ACP46353.1.
RefSeq	YP_002838275.1. NC_012622.1.
3D structure databases
ProteinModelPortal	C3N866.
ModBase	Search...
Protein-protein interaction databases
STRING	439386.YG5714_2101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACP46353; ACP46353; YG5714_2101.
GeneID	7807920.
KEGG	siy:YG5714_2101.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0624.
HOGENOM	HOG000105331.
KO	K05831.
OMA	GDSDLDH.
ProtClustDB	PRK00466.
Enzyme and pathway databases
BioCyc	SISL439386:GHF0-2183-MONOMER.
UniPathway	UPA00033; UER00039.
Family and domain databases
HAMAP	MF_01120. Acet-lys_deacetyl.
InterPro	IPR023556. Acetyl-lysine_deAcylase. IPR001261. ArgE/DapE_CS. IPR010175. DapE_lys_deAc. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01902. dapE-lys-deAc. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSK_SULIY

Accession

Primary (citable) accession number: C3N866

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program