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C3N866

- LYSK_SULIY

UniProt

C3N866 - LYSK_SULIY

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Protein
N-acetyl-lysine deacetylase
Gene
lysK, YG5714_2101
Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of N(2)-acetyllysine By similarity.

Catalytic activityi

N(2)-acetyl-L-lysine + H2O = acetate + L-lysine.UniRule annotation

Cofactori

Binds 2 zinc or cobalt ions per subunit By similarity.UniRule annotation
Glutathione By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Cobalt or zinc 1 By similarity
Active sitei70 – 701 By similarity
Metal bindingi92 – 921Cobalt or zinc 1 By similarity
Metal bindingi92 – 921Cobalt or zinc 2 By similarity
Active sitei122 – 1221Proton acceptor By similarity
Metal bindingi123 – 1231Cobalt or zinc 2 By similarity
Metal bindingi146 – 1461Cobalt or zinc 1 By similarity
Metal bindingi317 – 3171Cobalt or zinc 2 By similarity

GO - Molecular functioni

  1. cobalt ion binding Source: InterPro
  2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSISL439386:GHF0-2186-MONOMER.
UniPathwayiUPA00033; UER00039.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-lysine deacetylase (EC:3.5.1.-)
Gene namesi
Name:lysK
Ordered Locus Names:YG5714_2101
OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Taxonomic identifieri439386 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000002308: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346N-acetyl-lysine deacetylase
PRO_1000213618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439386.YG5714_2101.

Structurei

3D structure databases

ProteinModelPortaliC3N866.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000105331.
KOiK05831.
OMAiGDSDLDH.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01120. Acet_lys_deacetyl.
InterProiIPR023556. Acetyl-lysine_deAcylase.
IPR001261. ArgE/DapE_CS.
IPR010175. DapE_lys_deAc.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01902. dapE-lys-deAc. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3N866-1 [UniParc]FASTAAdd to Basket

« Hide

MQQEKELVKQ KAKELLLDLL SIYTPSKNET NATKFFEKIS NEFNLKLEIL    50
PDSNSFILGE GEILLASHVD TVPGYIEPKI ENEVIYGRGA VDAKGPLISM 100
IIAAWLLNEK GIKVMVSGLA DEESTSIGAK ELTLKNFNFK HIIVGEPSNG 150
TDIVVEYRGS IQLDIMCEST PEHSSSAKSN LIVDISKKII EVYKQPENYD 200
KPSIVPTIIR AGESYNVTPA KLYLHFDVRY AINNKRDDLI NEIKDKFQEC 250
GLKIVDETPP VKVSINNPVV KSLTRALLKQ NIKPRLVRKA GTSDMNILQK 300
ITTSIATYGP GNSMLEHTNQ EKITLDEIYI GVKTYMLAIE ELWQKS 346
Length:346
Mass (Da):38,769
Last modified:June 16, 2009 - v1
Checksum:iBDE8A5BEEBA0BAF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP46353.1.
RefSeqiYP_002838275.1. NC_012622.1.

Genome annotation databases

EnsemblBacteriaiACP46353; ACP46353; YG5714_2101.
GeneIDi7807920.
KEGGisiy:YG5714_2101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP46353.1 .
RefSeqi YP_002838275.1. NC_012622.1.

3D structure databases

ProteinModelPortali C3N866.
ModBasei Search...

Protein-protein interaction databases

STRINGi 439386.YG5714_2101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP46353 ; ACP46353 ; YG5714_2101 .
GeneIDi 7807920.
KEGGi siy:YG5714_2101.

Phylogenomic databases

eggNOGi COG0624.
HOGENOMi HOG000105331.
KOi K05831.
OMAi GDSDLDH.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00039 .
BioCyci SISL439386:GHF0-2186-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_01120. Acet_lys_deacetyl.
InterProi IPR023556. Acetyl-lysine_deAcylase.
IPR001261. ArgE/DapE_CS.
IPR010175. DapE_lys_deAc.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01902. dapE-lys-deAc. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.G.57.14 / Yellowstone #1.

Entry informationi

Entry nameiLYSK_SULIY
AccessioniPrimary (citable) accession number: C3N866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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