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C3N866

- LYSK_SULIY

UniProt

C3N866 - LYSK_SULIY

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Protein

N-acetyl-lysine deacetylase

Gene

lysK

Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of N(2)-acetyllysine.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + H2O = acetate + L-lysine.UniRule annotation

Cofactori

Binds 2 zinc or cobalt ions per subunit.UniRule annotation
Glutathione.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Cobalt or zinc 1UniRule annotation
Active sitei70 – 701UniRule annotation
Metal bindingi92 – 921Cobalt or zinc 1UniRule annotation
Metal bindingi92 – 921Cobalt or zinc 2UniRule annotation
Active sitei122 – 1221Proton acceptorUniRule annotation
Metal bindingi123 – 1231Cobalt or zinc 2UniRule annotation
Metal bindingi146 – 1461Cobalt or zinc 1UniRule annotation
Metal bindingi317 – 3171Cobalt or zinc 2UniRule annotation

GO - Molecular functioni

  1. cobalt ion binding Source: InterPro
  2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSISL439386:GHF0-2186-MONOMER.
UniPathwayiUPA00033; UER00039.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-lysine deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
Gene namesi
Name:lysKUniRule annotation
Ordered Locus Names:YG5714_2101
OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Taxonomic identifieri439386 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000002308: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346N-acetyl-lysine deacetylasePRO_1000213618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439386.YG5714_2101.

Structurei

3D structure databases

ProteinModelPortaliC3N866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. LysK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000105331.
KOiK05831.
OMAiGDSDLDH.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01120. Acet_lys_deacetyl.
InterProiIPR023556. Acetyl-lysine_deAcylase.
IPR001261. ArgE/DapE_CS.
IPR010175. DapE_lys_deAc.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01902. dapE-lys-deAc. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3N866-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQEKELVKQ KAKELLLDLL SIYTPSKNET NATKFFEKIS NEFNLKLEIL
60 70 80 90 100
PDSNSFILGE GEILLASHVD TVPGYIEPKI ENEVIYGRGA VDAKGPLISM
110 120 130 140 150
IIAAWLLNEK GIKVMVSGLA DEESTSIGAK ELTLKNFNFK HIIVGEPSNG
160 170 180 190 200
TDIVVEYRGS IQLDIMCEST PEHSSSAKSN LIVDISKKII EVYKQPENYD
210 220 230 240 250
KPSIVPTIIR AGESYNVTPA KLYLHFDVRY AINNKRDDLI NEIKDKFQEC
260 270 280 290 300
GLKIVDETPP VKVSINNPVV KSLTRALLKQ NIKPRLVRKA GTSDMNILQK
310 320 330 340
ITTSIATYGP GNSMLEHTNQ EKITLDEIYI GVKTYMLAIE ELWQKS
Length:346
Mass (Da):38,769
Last modified:June 16, 2009 - v1
Checksum:iBDE8A5BEEBA0BAF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP46353.1.
RefSeqiYP_002838275.1. NC_012622.1.

Genome annotation databases

EnsemblBacteriaiACP46353; ACP46353; YG5714_2101.
GeneIDi7807920.
KEGGisiy:YG5714_2101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001403 Genomic DNA. Translation: ACP46353.1 .
RefSeqi YP_002838275.1. NC_012622.1.

3D structure databases

ProteinModelPortali C3N866.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439386.YG5714_2101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP46353 ; ACP46353 ; YG5714_2101 .
GeneIDi 7807920.
KEGGi siy:YG5714_2101.

Phylogenomic databases

eggNOGi COG0624.
HOGENOMi HOG000105331.
KOi K05831.
OMAi GDSDLDH.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00039 .
BioCyci SISL439386:GHF0-2186-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_01120. Acet_lys_deacetyl.
InterProi IPR023556. Acetyl-lysine_deAcylase.
IPR001261. ArgE/DapE_CS.
IPR010175. DapE_lys_deAc.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01902. dapE-lys-deAc. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.G.57.14 / Yellowstone #1.

Entry informationi

Entry nameiLYSK_SULIY
AccessioniPrimary (citable) accession number: C3N866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3