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C3N866

- LYSK_SULIY

UniProt

C3N866 - LYSK_SULIY

Protein

N-acetyl-lysine deacetylase

Gene

lysK

Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the deacetylation of N(2)-acetyllysine.UniRule annotation

    Catalytic activityi

    N(2)-acetyl-L-lysine + H2O = acetate + L-lysine.UniRule annotation

    Cofactori

    Binds 2 zinc or cobalt ions per subunit.UniRule annotation
    Glutathione.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Cobalt or zinc 1UniRule annotation
    Active sitei70 – 701UniRule annotation
    Metal bindingi92 – 921Cobalt or zinc 1UniRule annotation
    Metal bindingi92 – 921Cobalt or zinc 2UniRule annotation
    Active sitei122 – 1221Proton acceptorUniRule annotation
    Metal bindingi123 – 1231Cobalt or zinc 2UniRule annotation
    Metal bindingi146 – 1461Cobalt or zinc 1UniRule annotation
    Metal bindingi317 – 3171Cobalt or zinc 2UniRule annotation

    GO - Molecular functioni

    1. cobalt ion binding Source: InterPro
    2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP
    3. metallopeptidase activity Source: InterPro
    4. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    Cobalt, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSISL439386:GHF0-2186-MONOMER.
    UniPathwayiUPA00033; UER00039.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-lysine deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
    Gene namesi
    Name:lysKUniRule annotation
    Ordered Locus Names:YG5714_2101
    OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
    Taxonomic identifieri439386 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000002308: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346N-acetyl-lysine deacetylasePRO_1000213618Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439386.YG5714_2101.

    Structurei

    3D structure databases

    ProteinModelPortaliC3N866.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20A family. LysK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0624.
    HOGENOMiHOG000105331.
    KOiK05831.
    OMAiGDSDLDH.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_01120. Acet_lys_deacetyl.
    InterProiIPR023556. Acetyl-lysine_deAcylase.
    IPR001261. ArgE/DapE_CS.
    IPR010175. DapE_lys_deAc.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01902. dapE-lys-deAc. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3N866-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQEKELVKQ KAKELLLDLL SIYTPSKNET NATKFFEKIS NEFNLKLEIL    50
    PDSNSFILGE GEILLASHVD TVPGYIEPKI ENEVIYGRGA VDAKGPLISM 100
    IIAAWLLNEK GIKVMVSGLA DEESTSIGAK ELTLKNFNFK HIIVGEPSNG 150
    TDIVVEYRGS IQLDIMCEST PEHSSSAKSN LIVDISKKII EVYKQPENYD 200
    KPSIVPTIIR AGESYNVTPA KLYLHFDVRY AINNKRDDLI NEIKDKFQEC 250
    GLKIVDETPP VKVSINNPVV KSLTRALLKQ NIKPRLVRKA GTSDMNILQK 300
    ITTSIATYGP GNSMLEHTNQ EKITLDEIYI GVKTYMLAIE ELWQKS 346
    Length:346
    Mass (Da):38,769
    Last modified:June 16, 2009 - v1
    Checksum:iBDE8A5BEEBA0BAF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001403 Genomic DNA. Translation: ACP46353.1.
    RefSeqiYP_002838275.1. NC_012622.1.

    Genome annotation databases

    EnsemblBacteriaiACP46353; ACP46353; YG5714_2101.
    GeneIDi7807920.
    KEGGisiy:YG5714_2101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001403 Genomic DNA. Translation: ACP46353.1 .
    RefSeqi YP_002838275.1. NC_012622.1.

    3D structure databases

    ProteinModelPortali C3N866.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439386.YG5714_2101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP46353 ; ACP46353 ; YG5714_2101 .
    GeneIDi 7807920.
    KEGGi siy:YG5714_2101.

    Phylogenomic databases

    eggNOGi COG0624.
    HOGENOMi HOG000105331.
    KOi K05831.
    OMAi GDSDLDH.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00039 .
    BioCyci SISL439386:GHF0-2186-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_01120. Acet_lys_deacetyl.
    InterProi IPR023556. Acetyl-lysine_deAcylase.
    IPR001261. ArgE/DapE_CS.
    IPR010175. DapE_lys_deAc.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01902. dapE-lys-deAc. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y.G.57.14 / Yellowstone #1.

    Entry informationi

    Entry nameiLYSK_SULIY
    AccessioniPrimary (citable) accession number: C3N866
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3