C3N7B7 (GCH1_SULIY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	YG5714_1855

Organism

Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) [Complete proteome] [HAMAP]

Taxonomic identifier

439386 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000204299
Sites
	Metal binding	89	1	Zinc By similarity
	Metal binding	92	1	Zinc By similarity
	Metal binding	163	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3N7B7 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: A54CA0B663B5C81A	FASTA	208	23,566
	10 20 30 40 50 60 MQKTELDDQK LVEEIARRIR EILELLGENP EREGLKETPE RVAKALLEMT SGLRTPPPQI 70 80 90 100 110 120 KVFSLGEDGE VYEKNQIVLI KDVNFSSLCE HHMLPIIGKI HVAYIVSNSG KVAGFSKIIR 130 140 150 160 170 180 IVNYYSSRLQ IQERLVEQIA DAIMNSEIKP KGVMVIGNAI HMCSYVRGVK DKEAKLVSVA 190 200 YRGLFKTNRA LQNHVFRLLD NANKVNLL

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Y.G.57.14 / Yellowstone #1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001403 Genomic DNA. Translation: ACP46111.1.
RefSeq	YP_002838033.1. NC_012622.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C3N7B7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7807258.
GenomeReviews	Gene locus YG5714_1855 in contig CP001403_GR.
KEGG	siy:YG5714_1855.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HEEMIIV.
ProtClustDB	PRK09347.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_SULIY

Accession

Primary (citable) accession number: C3N7B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	November 16, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program