C3N6P1 (C3N6P1_SULIA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

M1627_1791

Organism

Sulfolobus islandicus (strain M.16.27) [Complete proteome] [HAMAP]

Taxonomic identifier

427318 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405
Ligand	Magnesium HAMAP MF_01405 Manganese HAMAP MF_01405 Metal-binding HAMAP MF_01405 Nucleotide-binding HAMAP MF_01405
Molecular function	Hydrolase HAMAP MF_01405 RuleBase RU003781
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	12 – 17	6	Substrate binding By similarity HAMAP MF_01405
	Region	70 – 71	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	41	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	70	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	148	1	Substrate By similarity HAMAP MF_01405
	Binding site	168	1	Substrate By similarity HAMAP MF_01405
	Binding site	174	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	C3N6P1 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: EC903DE9297967A3	FASTA	192	21,974
	10 20 30 40 50 60 MLRRDVRIGV VTSNENKFME LKELAKSFNI ELEQLKGEKI EIQSDNLEEI SKTAAYLAYL 70 80 90 100 110 120 TFRRPLIVDD SGLFIETLQN FPGPYTNFVK NTIGLKGILK LLEDLKDRSA YFMTVLTFTD 130 140 150 160 170 180 GKIIKTFNGI VKGVISEEIR GNSGFGFDPI FIPEGEKRTF AEMSLEEKNK YSHRARAFAK 190 FADFLMSYLE KA

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001401 Genomic DNA. Translation: ACP55666.1.
RefSeq	YP_002843711.1. NC_012632.1.
3D structure databases
ProteinModelPortal	C3N6P1.
ModBase	Search...
Protein-protein interaction databases
STRING	C3N6P1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7812455.
GenomeReviews	Gene locus M1627_1791 in contig CP001401_GR.
KEGG	sim:M1627_1791.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VEDSGFF.
ProtClustDB	CLSK802721.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C3N6P1_SULIA

Accession

Primary (citable) accession number: C3N6P1

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)