C3N6A4 (HIS2_SULIA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	M1627_1649

Organism

Sulfolobus islandicus (strain M.16.27) [Complete proteome] [HAMAP]

Taxonomic identifier

427318 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 94	94	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000213290

Sequences

	Sequence		Length	Mass (Da)
	C3N6A4 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 9135F5C52545FC4E	FASTA	94	10,826
	10 20 30 40 50 60 MSNEIVDKLY KVILDRIEKR PTGSYTVEIV NKGKAYVARK VGEESVETIV ASLAENKERF 70 80 90 ISEVADLIYH LLVLMALEGV TPDDIYRELE RRRK

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M.16.27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001401 Genomic DNA. Translation: ACP55529.1.
RefSeq	YP_002843574.1. NC_012632.1.
3D structure databases
ProteinModelPortal	C3N6A4.
ModBase	Search...
Protein-protein interaction databases
STRING	C3N6A4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7814640.
GenomeReviews	Gene locus M1627_1649 in contig CP001401_GR.
KEGG	sim:M1627_1649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EMRRREN.
ProtClustDB	CLSK802782.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_SULIA

Accession

Primary (citable) accession number: C3N6A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	November 16, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program