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C3N5G1

- GCSPA_SULIA

UniProt

C3N5G1 - GCSPA_SULIA

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Sulfolobus islandicus (strain M.16.27)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciSISL427318:GH3D-1398-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:M1627_1353
    OrganismiSulfolobus islandicus (strain M.16.27)
    Taxonomic identifieri427318 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000002307: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000212664Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi427318.M1627_1353.

    Structurei

    3D structure databases

    ProteinModelPortaliC3N5G1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3N5G1-1 [UniParc]FASTAAdd to Basket

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    MYKHPWLPNL DLIDEMLKEI GVNSLDELFN DIPAEIKINR LLNVAKGKPL    50
    SEYEIEKEIN EKVKKNVELQ APPFIGAGIC PHYIPNVVKF IIGRSEFYTS 100
    YTPYQPEISQ GLLQALFEYQ SLMAELLDMD VVNASMYDWG SALAEAVLMA 150
    NRINGKKTVL VPENANPFHK EVVRTWIGGK GIKIEEVKYD KNSGELDLED 200
    LEKKSNIDDI SAIYIQQPNF FGIFESNIEH VIDVAKHKRA LSIVGVNLLS 250
    LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGVFAVRW DMSLVRQMPG 300
    RIVGITKDTN GKMGFTLILQ TREQFIKREK ATSNITTNEA LLAIANAVYL 350
    SLLGKEGMRE LAEEIYFRSH YAAKKLTEID NVSMPFRSDF FEEFAIRFPI 400
    EYDKISNKLK ERKLQGGLKL SDYTSLFCVT EVHDKKSIDL LVSTIQEMIN 450
    GVETS 455
    Length:455
    Mass (Da):51,292
    Last modified:June 16, 2009 - v1
    Checksum:iCF30BA22D9E4B13C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001401 Genomic DNA. Translation: ACP55236.1.
    RefSeqiYP_002843281.1. NC_012632.1.

    Genome annotation databases

    EnsemblBacteriaiACP55236; ACP55236; M1627_1353.
    GeneIDi7812564.
    KEGGisim:M1627_1353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001401 Genomic DNA. Translation: ACP55236.1 .
    RefSeqi YP_002843281.1. NC_012632.1.

    3D structure databases

    ProteinModelPortali C3N5G1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 427318.M1627_1353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP55236 ; ACP55236 ; M1627_1353 .
    GeneIDi 7812564.
    KEGGi sim:M1627_1353.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.

    Enzyme and pathway databases

    BioCyci SISL427318:GH3D-1398-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M.16.27.

    Entry informationi

    Entry nameiGCSPA_SULIA
    AccessioniPrimary (citable) accession number: C3N5G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3