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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Sulfolobus islandicus (strain M.16.27)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Sirohydrochlorin cobaltochelatase (cbiX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (cbiT)
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:M1627_0111
OrganismiSulfolobus islandicus (strain M.16.27)
Taxonomic identifieri427318 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000002307 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129401 – 349Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST349

Proteomic databases

PRIDEiC3N0H9

Structurei

3D structure databases

SMRiC3N0H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG093Z05FA

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

C3N0H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIINSLKRFG ITTGAAASAA AKAAVIGLLN REKRNTVVIP TPIGLRLEIP
60 70 80 90 100
VEKVEIDSGI ACAEVKKFSG DNPDILDGLA IRCCAKLNES NEIVIVGGKG
110 120 130 140 150
VGKVTRSGLK ATMGETAISP TVRDMVINAI REVTDKGIQI TIEVPNGDII
160 170 180 190 200
AENTLNKMVG IVGGISILGT TGIETPVSDD DYLEHIKCEL NVIRQSYDFV
210 220 230 240 250
VIAPGNSAAK YASKLFDSNS IIKVGDRIGD SIKLASSVFR KVILAGLPAK
260 270 280 290 300
LLKVYAGIFN THFSQGDARL ESLTHASVLA GLPYDVLTKI TNALSVEEAF
310 320 330 340
TYMTKEQRRK VMKIVAEKIL SRIKSFNGDI NFCVIIFDYD GESLSRVGC
Length:349
Mass (Da):37,432
Last modified:June 16, 2009 - v1
Checksum:iBC5895F96867E63C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001401 Genomic DNA Translation: ACP54140.1
RefSeqiWP_012710290.1, NC_012632.1

Genome annotation databases

EnsemblBacteriaiACP54140; ACP54140; M1627_0111
GeneIDi7813722
KEGGisim:M1627_0111

Similar proteinsi

Entry informationi

Entry nameiCBID_SULIA
AccessioniPrimary (citable) accession number: C3N0H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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