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Protein

NAD kinase

Gene

nadK

Organism
Sulfolobus islandicus (strain M.16.27)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei50NADUniRule annotation1
Binding sitei138NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi110 – 111NADUniRule annotation2
Nucleotide bindingi149 – 154NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:M1627_0035
OrganismiSulfolobus islandicus (strain M.16.27)
Taxonomic identifieri427318 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000002307 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002054251 – 249NAD kinaseAdd BLAST249

Proteomic databases

PRIDEiC3MZX9

Structurei

3D structure databases

SMRiC3MZX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000270621
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z0ENK

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

C3MZX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKIVSKPT SQLNNIIEKI KNISTKLGFE VVDKDFDYVI AVGGDGTLLR
60 70 80 90 100
AVKQNKPVIA VKAGRRGLLM DVPVDKFEEA LLRLKKGDYE EEEYMLLEMI
110 120 130 140 150
YNDKVELGFN EVGILYDRPE AIKVGISFDT ERVSVEGDGV LVSTPQGSSG
160 170 180 190 200
WGMSATNSLL YKDLSAIEII FVNPIFYYLR SVVIPPKPLT LRLEDKGYPQ
210 220 230 240
TARAVVDGEV VTLIKTNQEI TVRVSQRKAK ILRFFKLDLI GEVLHAYHI
Length:249
Mass (Da):27,978
Last modified:June 16, 2009 - v1
Checksum:i8C86C7F578839319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001401 Genomic DNA Translation: ACP54064.1
RefSeqiWP_012710214.1, NC_012632.1

Genome annotation databases

EnsemblBacteriaiACP54064; ACP54064; M1627_0035
GeneIDi8759874
KEGGisim:M1627_0035

Similar proteinsi

Entry informationi

Entry nameiNADK_SULIA
AccessioniPrimary (citable) accession number: C3MZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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