Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

lig

Organism
Sulfolobus islandicus (strain M.16.27)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1
Active sitei260N6-AMP-lysine intermediateUniRule annotation1
Binding sitei265ATPUniRule annotation1
Binding sitei280ATPUniRule annotation1
Binding sitei310ATPUniRule annotation1
Binding sitei350ATPUniRule annotation1
Binding sitei427ATPUniRule annotation1
Binding sitei433ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:M1627_2023
OrganismiSulfolobus islandicus (strain M.16.27)
Taxonomic identifieri427318 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000002307 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002059551 – 601DNA ligaseAdd BLAST601

Structurei

3D structure databases

ProteinModelPortaliC3MZR1
SMRiC3MZR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C3MZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKVIAEYF DKLEKISSRL QLTALLADLL SKSDKAIIDK VVYIIQGKLW
60 70 80 90 100
PDFLGYPELG IGEKFLIKAI SIATNTDENS VENLYKSIGD LGEVARRLKS
110 120 130 140 150
KQQSTGILGF LGTSSKESLK VDEVYSTLSK VALTTGEGSR DLKIRLLAGL
160 170 180 190 200
LKKADPLEAK FLVRFVEGRL RVGIGDATVL DAMAIAFGGG QSASEIVERA
210 220 230 240 250
YNLRADLGNI AKIIVEKGIE ALKTLKPEVG IPIRPMLAER LSNPEEILKK
260 270 280 290 300
VGGSALVDYK YDGERAQIHK KDDKIFIFSR RLENITSQYP DVVEYISKYT
310 320 330 340 350
EGKEFIIEGE IVAVDPESGE MRSFQELMHR KRKSDIYEAI KEYPVNVFLF
360 370 380 390 400
DLMYYEDVDY TTKPLEVRRK LLESIVKPND YVKIAHHIQV NNVEDLKSFF
410 420 430 440 450
YRAISEGGEG VMVKAIGKDA IYQAGARGWL WIKLKRDYQS EMADTVDLVV
460 470 480 490 500
VGGFYGKGKR GGKISSLLMA AYNPKTDTFE SVCKVASGFS DEQLDELQKK
510 520 530 540 550
LMEIKRDIKH PRVNSKMEPD IWVEPVYVAE IIGAEITISP LHTCCQDVVE
560 570 580 590 600
KDAGLSIRFP RFIRWRDDKS PEDATTTDEI LEMYNKQPKK KIESPPIDES

V
Length:601
Mass (Da):67,716
Last modified:June 16, 2009 - v1
Checksum:i0D257FC878FA12FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001401 Genomic DNA Translation: ACP55893.1
RefSeqiWP_012711916.1, NC_012632.1

Genome annotation databases

EnsemblBacteriaiACP55893; ACP55893; M1627_2023
GeneIDi7812129
KEGGisim:M1627_2023

Similar proteinsi

Entry informationi

Entry nameiDNLI_SULIA
AccessioniPrimary (citable) accession number: C3MZR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health