C3MZF0 (AROA_SULIA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	M1627_1911

Organism

Sulfolobus islandicus (strain M.16.27) [Complete proteome] [HAMAP]

Taxonomic identifier

427318 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000204171

Sequences

	Sequence		Length	Mass (Da)
	C3MZF0 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 81BA564E78E8D8C5	FASTA	414	45,322
	10 20 30 40 50 60 MIVRIYPSEI SGTIKAPQSK SLAIRLIFLS LFTRIHLHNL VLSEDVIDAI NSVRALGVEV 70 80 90 100 110 120 KNNSEFIPPE KLEIKKKFIK LKGSGTTLRM LIPIVAAIGG EVTIDAEESL RRRPLKRIVE 130 140 150 160 170 180 ALTNYGISFS SSSLPLTITG KLSSYNIKIS GDESSQYISG LIYALHILNG GSIEILPPIS 190 200 210 220 230 240 SKSYILLTVD LFNRFGSNVK FYGNKIHINP NNLVEFQGEV AGDYGLASFY ALSALVSGGR 250 260 270 280 290 300 TTIVNLWEPK EYFGDHSIVK ILKEMGATSE YLDGKWYVEA KDKYSSIKVN IDDAPDLAMT 310 320 330 340 350 360 IAGLAAIAEG TSEITGIERL RIKESDRIES IRKVLGLYGV GSEVKSNSIL IFGINKRMLS 370 380 390 400 410 SPITDCLNDH RVAMMSSALA LVNGGVITSA ECVSKSNPNY WQDLLSLNAK ISIE

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M.16.27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001401 Genomic DNA. Translation: ACP55782.1.
RefSeq	YP_002843827.1. NC_012632.1.
3D structure databases
ProteinModelPortal	C3MZF0.
ModBase	Search...
Protein-protein interaction databases
STRING	C3MZF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7812253.
GenomeReviews	Gene locus M1627_1911 in contig CP001401_GR.
KEGG	sim:M1627_1911.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FADHRIA.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_SULIA

Accession

Primary (citable) accession number: C3MZF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	November 16, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program