C3MYE1 (C3MYE1_SULIM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

M1425_1954

Organism

Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) [Complete proteome] [HAMAP]

Taxonomic identifier

427317 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515 EMBL ACP38698.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	202	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	255	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	240	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	212	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	224	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	282	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	321	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	C3MYE1 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 7645884683A60F93	FASTA	336	37,818
	10 20 30 40 50 60 MVTFPFLRPR RLRKNKLVRD LVAETTLFQD DLVLPIFIKE SINEPEQITS MPGVYRYPPN 70 80 90 100 110 120 DKLVNYVQDS YENGIRSIIL FGIPSYKDEI ASSAYDKNGV IQRAVKIIKD SFKDKIIVIT 130 140 150 160 170 180 DECTDEYTSH GHCGLVNYNN GCYVIDNDES LKIHAKIALS QAEAGADIIA PSSMMDGVVK 190 200 210 220 230 240 AIRDALDGAG YNDILIMSYS VKYASIMYGP FRDAAYSKPA FGDRRGYQMD PRNAFEALKE 250 260 270 280 290 300 ARLDIEEGAD ILMVKPAHTY LDVIRLVKDH FPEYPLAAYH VSGEYSMIKA AAINGWIDER 310 320 330 TAVLEITTAI KRAGADLIIT YYANDIVRWI KEGVPF

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001400 Genomic DNA. Translation: ACP38698.1.
RefSeq	YP_002829996.1. NC_012588.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C3MYE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7795902.
GenomeReviews	Gene locus M1425_1954 in contig CP001400_GR.
KEGG	sia:M1425_1954.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HCGVVEN.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3MYE1_SULIM

Accession

Primary (citable) accession number: C3MYE1

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)