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Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99CitrullineUniRule annotation1
Binding sitei129ATP; via amide nitrogenUniRule annotation1
Binding sitei131AspartateUniRule annotation1
Binding sitei135AspartateUniRule annotation1
Binding sitei135CitrullineUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei139CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei195CitrullineUniRule annotation1
Binding sitei268CitrullineUniRule annotation1
Binding sitei280CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:M1425_1496Imported
OrganismiSulfolobus islandicus (strain M.14.25 / Kamchatka #1)Imported
Taxonomic identifieri427317 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001350 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3MW24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230093.
KOiK01940.
OMAiGVGRIDM.
OrthoDBiPOG093Z02NI.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR11587. PTHR11587. 1 hit.
PfamiView protein in Pfam
PF00764. Arginosuc_synth. 1 hit.
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiView protein in PROSITE
PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MW24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISIVFKLLL YPFCEMKIVL AYSGGLDTTV SIRWLKETFK AEVITVTVDV
60 70 80 90 100
GQKDDFKKIE ERAYIAGASK HYTIDAIKEF ANNYISYAIK LNGLYEGVYP
110 120 130 140 150
LSTALARPLI AEKVVEVAKK EKADAVAHGS TSKGNDQVRF DLTVKALYPD
160 170 180 190 200
VKIIAPARIW SMTREDEIKY AKEKGIPIKV ESSKYSIDEN LWGRSIEGDI
210 220 230 240 250
ISDPSVEVTE DAFEWTKQIA NNKEIISIEF INGVPTAVDG EQMELHKLIG
260 270 280 290 300
LLNLKFGNHG FGRVEHIENR VVGFKSREVY EVPAALGLIY SHIDLEKTIY
310 320 330 340 350
TPTELRFKKY VDQLWSDLVY QGLWFEPLRE TLHKIADEMN KWIAGEVRVE
360 370 380 390 400
VNNGSFRILG RKSDYSPYSE KLASYNKGWY PSDEMARGFI EIWGMHSLIA

RRVRGL
Length:406
Mass (Da):46,253
Last modified:June 16, 2009 - v1
Checksum:i37563CB1B05B340E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001400 Genomic DNA. Translation: ACP38246.1.
RefSeqiWP_012711491.1. NC_012588.1.

Genome annotation databases

EnsemblBacteriaiACP38246; ACP38246; M1425_1496.
GeneIDi7814545.
KEGGisia:M1425_1496.

Similar proteinsi

Entry informationi

Entry nameiC3MW24_SULIM
AccessioniPrimary (citable) accession number: C3MW24
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported