Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C3MUU9

- GCSPB_SULIM

UniProt

C3MUU9 - GCSPB_SULIM

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSISL427317:GI7C-1339-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:M1425_1304
    OrganismiSulfolobus islandicus (strain M.14.25 / Kamchatka #1)
    Taxonomic identifieri427317 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001350: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000212676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi427317.M1425_1304.

    Structurei

    3D structure databases

    ProteinModelPortaliC3MUU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiLGETPWD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3MUU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVWRQAKWDE PLIFELNNSG ANRQGLLINK DDEIRSEIKE MKIPKNLLRE    50
    NGPNLPSLSE LEVVRHFIRL SQMNFGVDVG IMPLGSCTMK YNPKIEEKAT 100
    AITESHHPLE DEDHVQGILE MIYELQNWFS EITGMDECSL QVPAGSAGEF 150
    AGVLMIKKYH EDHNRNYKDT MLVADTAHGT NPASAAMAGY KVMYVKSNGE 200
    GLVDMDILRE IVNDKTAGFM LTNPNTLGLF EENILEISKI IHSANAILYY 250
    DGANLNGVLG IARPGDMGFD IVHLNLHKTF AVPHGGGGPG AGAICAKGEL 300
    VNYLPYPMVE KVNGKYRLSK IPKNSVGKIA TFYGNVGNLA RSFAYLLGLG 350
    PQGVQMVGKM STLATNYLIA KLRDIKELEL IAPNRHRKHE VVFSVKQLME 400
    NYGVSANDVA KALLDSGFYA PTIYFPPIIE EALMIEPTET ESKETLDMFA 450
    EALKKIVEDA KRNPEQLLKS PSNTSIARLD QAYANHPSTI TPTYRVLKLR 500
    RMGKINYLK 509
    Length:509
    Mass (Da):56,584
    Last modified:June 16, 2009 - v1
    Checksum:i2181A9B4FA39ABD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001400 Genomic DNA. Translation: ACP38059.1.
    RefSeqiYP_002829357.1. NC_012588.1.

    Genome annotation databases

    EnsemblBacteriaiACP38059; ACP38059; M1425_1304.
    GeneIDi7793742.
    KEGGisia:M1425_1304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001400 Genomic DNA. Translation: ACP38059.1 .
    RefSeqi YP_002829357.1. NC_012588.1.

    3D structure databases

    ProteinModelPortali C3MUU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 427317.M1425_1304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP38059 ; ACP38059 ; M1425_1304 .
    GeneIDi 7793742.
    KEGGi sia:M1425_1304.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi LGETPWD.

    Enzyme and pathway databases

    BioCyci SISL427317:GI7C-1339-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M.14.25 / Kamchatka #1.

    Entry informationi

    Entry nameiGCSPB_SULIM
    AccessioniPrimary (citable) accession number: C3MUU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3