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C3MTP3

- NADK_SULIM

UniProt

C3MTP3 - NADK_SULIM

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Protein

NAD kinase

Gene

nadK

Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptorUniRule annotation
Binding sitei50 – 501NADUniRule annotation
Binding sitei138 – 1381NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NADUniRule annotation
Nucleotide bindingi110 – 1112NADUniRule annotation
Nucleotide bindingi149 – 1546NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSISL427317:GI7C-35-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:M1425_0035
OrganismiSulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Taxonomic identifieri427317 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001350: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249NAD kinasePRO_1000205428Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi427317.M1425_0035.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000270621.
KOiK00858.
OMAiFPRENFL.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MTP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVKIVSKPT SQLNNIIEKI KNISTKLGFE VVDKDFDYVI AVGGDGTLLR
60 70 80 90 100
AVKQNKPVIA VKAGRRGLLM DVPVDKFEEA LLRLKKGDYE EEEYMLLEMI
110 120 130 140 150
YNDKVELGFN EVGILYDRPE AIKVGISFDT ERVSVEGDGV LVSTPQGSSG
160 170 180 190 200
WGMSATNSLL YKDLSAIEII FVNPIFYYLR SVVIPPKPLT LRLEDKGYPQ
210 220 230 240
TARAVVDGEV VTLIKTNQEI TVRVSQRKAK ILRFFKLDLI GEVLHAYHI
Length:249
Mass (Da):27,978
Last modified:June 16, 2009 - v1
Checksum:i8C86C7F578839319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001400 Genomic DNA. Translation: ACP36927.1.
RefSeqiYP_002828225.1. NC_012588.1.

Genome annotation databases

EnsemblBacteriaiACP36927; ACP36927; M1425_0035.
GeneIDi7795413.
KEGGisia:M1425_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001400 Genomic DNA. Translation: ACP36927.1 .
RefSeqi YP_002828225.1. NC_012588.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 427317.M1425_0035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP36927 ; ACP36927 ; M1425_0035 .
GeneIDi 7795413.
KEGGi sia:M1425_0035.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000270621.
KOi K00858.
OMAi FPRENFL.

Enzyme and pathway databases

BioCyci SISL427317:GI7C-35-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M.14.25 / Kamchatka #1.

Entry informationi

Entry nameiNADK_SULIM
AccessioniPrimary (citable) accession number: C3MTP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3