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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

LS215_1988

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341MagnesiumUniRule annotation
Metal bindingi64 – 641MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSISL429572:GHOW-2061-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:LS215_1988
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001747 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Geranylgeranylglyceryl phosphate synthasePRO_1000202943Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC3MRH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 1887Glycerol-1-phosphate bindingUniRule annotation
Regioni213 – 2142Glycerol-1-phosphate bindingUniRule annotation
Regioni235 – 2362Glycerol-1-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MRH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRKKKMKL KGKVKKYLMD KLNDNEKLHF SLLDPFKINS SEELKYIAKN
60 70 80 90 100
LYNVGTDAFL IGGTLGVSKD KLDFVISLLD DYEIPKIIFP SNINLLSEKA
110 120 130 140 150
DALLFLSLLN SDDIYYVIGA QIVAAPIIKM LQMEVIPTAY VIVGHGGTAA
160 170 180 190 200
HIGKARVIPY DNFELATAYT LAAEYLGMDF VYLEAGSGAP EPIRPEMISF
210 220 230 240 250
IKKASSIPLI IGGGIRSVEV ALKLVEAGAN IIVTGNIIER DVDKAIKIIR

GIKNK
Length:255
Mass (Da):28,059
Last modified:June 16, 2009 - v1
Checksum:iEC3EC767A2B60CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35983.1.
RefSeqiWP_012714014.1. NC_012589.1.

Genome annotation databases

EnsemblBacteriaiACP35983; ACP35983; LS215_1988.
GeneIDi8761940.
KEGGisis:LS215_1988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35983.1.
RefSeqiWP_012714014.1. NC_012589.1.

3D structure databases

ProteinModelPortaliC3MRH0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP35983; ACP35983; LS215_1988.
GeneIDi8761940.
KEGGisis:LS215_1988.

Phylogenomic databases

HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciSISL429572:GHOW-2061-MONOMER.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L.S.2.15 / Lassen #1.

Entry informationi

Entry nameiGGGPS_SULIL
AccessioniPrimary (citable) accession number: C3MRH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: July 6, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.