C3MRB4 (C3MRB4_SULIL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase HAMAP MF_00214
Short name=3-dehydroquinase HAMAP MF_00214
EC=4.2.1.10 HAMAP MF_00214

Alternative name(s):
Type I DHQase HAMAP MF_00214

Gene names

Name:	aroD HAMAP MF_00214
Ordered Locus Names:	LS215_1932

Organism

Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) [Complete proteome] [HAMAP] EMBL ACP35927.1

Taxonomic identifier

429572 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family. HAMAP MF_00214

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00214
Ligand	Schiff base HAMAP MF_00214
Molecular function	Lyase HAMAP MF_00214 EMBL ACP35927.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	114	1	Proton acceptor By similarity HAMAP MF_00214
	Active site	140	1	Schiff-base intermediate with substrate By similarity HAMAP MF_00214

Sequences

	Sequence		Length	Mass (Da)
	C3MRB4 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 66F5A83EE64E3E68	FASTA	220	25,329
	10 20 30 40 50 60 MRPLIVASLP IKKIEDLKLI GNFLDADLIE LRLDYLKDRE VSVISDYFEF LDKYKNKLII 70 80 90 100 110 120 TLRDKAEGGI NELADELKIS LLKELYDKQF LYDVEVSFLQ KHNVPYDNAI VSIHYFNYLP 130 140 150 160 170 180 TSEKVKEIVS KFYEKAFSVK IAVLGLKGYK EVILPLLEYE NVTVIPMSNN PLERIAVGLL 190 200 210 220 GSKLVYSYAI EPLAQGQLYY KKVIQIFDYI NNIITSSSVT

References

[1]

"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: L.S.2.15 EMBL ACP35927.1.

[2]

US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Anderson I., Whitaker R.J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: L.S.2.15 EMBL ACP35927.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001399 Genomic DNA. Translation: ACP35927.1.
RefSeq	YP_002832572.1. NC_012589.1.
3D structure databases
ProteinModelPortal	C3MRB4.
ModBase	Search...
Protein-protein interaction databases
STRING	C3MRB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7799576.
GenomeReviews	Gene locus LS215_1932 in contig CP001399_GR.
KEGG	sis:LS215_1932.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ILYDVEA.
ProtClustDB	PRK13576.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3MRB4_SULIL

Accession

Primary (citable) accession number: C3MRB4

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)