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C3MQI8 (C3MQI8_SULIL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP MF_00079
Short name=ATP-PRT HAMAP MF_00079
Short name=ATP-PRTase HAMAP MF_00079
EC=2.4.2.17 HAMAP MF_00079
Gene names
Name:hisG HAMAP MF_00079
Ordered Locus Names:LS215_1647
OrganismSulfolobus islandicus (strain L.S.2.15 / Lassen #1) [Complete proteome] [HAMAP] EMBL ACP35651.1
Taxonomic identifier429572 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP MF_00079

Sequences

Sequence LengthMass (Da)Tools
C3MQI8 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 99E6CAFB48F85AF2

FASTA28631,415
        10         20         30         40         50         60 
MKIAIPNKGR LQQPTLQFLQ SVGIKPLASD DRALIVPTSW EGVQLVMIRT EDIPNIVETG 

        70         80         90        100        110        120 
ATELGITGHD YVIESSADVE ELIKLDFGRS KIVLAVPQTW SENSVEELKV REFRVATKYY 

       130        140        150        160        170        180 
NIAKEYVRKK ELNAKVVKIS GAAEVMPSLG AADAIIDVMS TGTTLKLHGL KAIDIIMDSY 

       190        200        210        220        230        240 
AVVIGNRNWI KNDEADRINL LLTMMKGAIA AKGKKMIFMN VPDNRLDGVI NSLPAMLAPA 

       250        260        270        280 
ITRLSRSDIW EVITVADEDI LPEVIAKVKA AGARDIVVID IEKVVK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001399 Genomic DNA. Translation: ACP35651.1.
RefSeqYP_002832296.1. NC_012589.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC3MQI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7799281.
GenomeReviewsGene locus LS215_1647 in contig CP001399_GR.
KEGGsis:LS215_1647.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIMLHAPS.
ProtClustDBPRK00489.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3MQI8_SULIL
AccessionPrimary (citable) accession number: C3MQI8
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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