C3MQE9 (C3MQE9_SULIL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741
EC=6.3.3.1 HAMAP MF_00741

Alternative name(s):
AIR synthase HAMAP MF_00741
AIRS HAMAP MF_00741
Phosphoribosyl-aminoimidazole synthetase HAMAP MF_00741

Gene names

Name:	purM HAMAP MF_00741
Ordered Locus Names:	LS215_1607

Organism

Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) [Complete proteome] [HAMAP] EMBL ACP35612.1

Taxonomic identifier

429572 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family. HAMAP MF_00741

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00741
Cellular component	Cytoplasm HAMAP MF_00741
Ligand	ATP-binding HAMAP MF_00741 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00741 EMBL ACP35612.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C3MQE9 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: D64699A8DAC8EC2A	FASTA	322	35,376
	10 20 30 40 50 60 MSEEYKKAGV DLERLRNYHN AISQIISSTY KNTIVGAGHY SGVIKIGNLN IAMHTDGVGT 70 80 90 100 110 120 KTSLALQTGI IKPVGIDCVA MNINDLICVG AKPVALVDYI ALEKPMDNVI NEIINGIVQG 130 140 150 160 170 180 AKDADVEVIG GETAIMPDVI RGFDLSCTAI GVVDNLKTGV DIKPGDYILG LESNGIHSNG 190 200 210 220 230 240 YSLVRKLIEE GKISLDEYKR ELLKPTRIYA KQVLEVMNMI KGAAHITGGA FTKLKRLTSY 250 260 270 280 290 300 KIVLNMPEPP EIFKIIEKAG VPHEEMYKVF NMGIGIVLFI SEELMKEVKT KLERYGTVYE 310 320 LGRVYNGNGI TIKTYKNEIL RV

References

[1]

"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: L.S.2.15 EMBL ACP35612.1.

[2]

US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Anderson I., Whitaker R.J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: L.S.2.15 EMBL ACP35612.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001399 Genomic DNA. Translation: ACP35612.1.
RefSeq	YP_002832257.1. NC_012589.1.
3D structure databases
ProteinModelPortal	C3MQE9.
ModBase	Search...
Protein-protein interaction databases
STRING	C3MQE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7799241.
GenomeReviews	Gene locus LS215_1607 in contig CP001399_GR.
KEGG	sis:LS215_1607.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GIDMIAM.
ProtClustDB	PRK05385.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C3MQE9_SULIL

Accession

Primary (citable) accession number: C3MQE9

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)