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UniProtKB - C3MQE6 (C3MQE6_SULIL)

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99CitrullineUniRule annotation1
Binding sitei129ATP; via amide nitrogenUniRule annotation1
Binding sitei131AspartateUniRule annotation1
Binding sitei135AspartateUniRule annotation1
Binding sitei135CitrullineUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei139CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei195CitrullineUniRule annotation1
Binding sitei268CitrullineUniRule annotation1
Binding sitei280CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPUniRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:LS215_1604Imported
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)Imported
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus ›
Proteomesi
  • UP000001747 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3MQE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230093.
KOiK01940.
OMAiGVGRIDM.
OrthoDBiPOG093Z02NI.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR11587. PTHR11587. 1 hit.
PfamiView protein in Pfam
PF00764. Arginosuc_synth. 1 hit.
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiView protein in PROSITE
PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MQE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISIVFKLLL YPFCEMKIVL AYSGGLDTTV SIRWLKETFK AEVITVTVDV 
        60         70         80         90        100
GQKDDFKKIE ERAYIAGASK HYTIDAIKEF ANNYISYAIK LNGLYEGVYP 
       110        120        130        140        150
LSTALARPLI AEKVVEVAKK EKADAVAHGS TSKGNDQVRF DLTVKALYPD 
       160        170        180        190        200
VKIIAPARIW SMTREDEIKY AKEKGIPIKV ESSKYSIDEN LWGRSIEGDI 
       210        220        230        240        250
ISDPSVEVTE DAFEWTKQIA NNKEIISIEF SNGVPTAVDG EQMELHKLIG 
       260        270        280        290        300
LLNLKFGNHG FGRVEHIENR VVGFKSREVY EVPAALGLIY SHIDLEKTIY 
       310        320        330        340        350
TPTELRFKKY VDQLWSDLVY QGLWFEPLRE TLHKIADEMN KWIAGEVRVE 
       360        370        380        390        400
VNNGSFRILG RKSDYSPYSE KLASYNKGWY PSDEMARGFI EIWGMHSLIA 

RRVRGL
Length:406
Mass (Da):46,227
Last modified:June 16, 2009 - v1
Checksum:iF1868C10CC2AE2D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35609.1.
RefSeqiWP_012713786.1. NC_012589.1.

Genome annotation databases

EnsemblBacteriaiACP35609; ACP35609; LS215_1604.
GeneIDi8761532.
KEGGisis:LS215_1604.

Similar proteinsi

Entry informationi

Entry nameiC3MQE6_SULIL
AccessioniPrimary (citable) accession number: C3MQE6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported