C3MPU9 (OGG1_SULIL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

1. 8-oxoguanine DNA glycosylase
   EC=3.2.2.-
2. DNA-(apurinic or apyrimidinic site) lyase
   Short name=AP lyase
   EC=4.2.99.18

Gene names

Name:	ogg
Ordered Locus Names:	LS215_1404

Organism

Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) [Complete proteome] [HAMAP]

Taxonomic identifier

429572 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus islandicus

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241
Catalytic activity	The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241
Sequence similarities	Belongs to the type-2 OGG1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA-(apurinic or apyrimidinic site) lyase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, hydrolyzing N-glycosyl compounds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241		PRO_1000204471
Sites
	Active site	128	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3MPU9 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: D56EDB4A5C5A4562	FASTA	207	24,071
	10 20 30 40 50 60 MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS AYQALNCLGD 70 80 90 100 110 120 KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL KEEITPLADS DQQLAREKLL 130 140 150 160 170 180 NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI DFMRRIGAIG ETNVKHLSKS RYISLESVLK 190 200 SIALNLNISV GILDLFIWYK ETNTIVK

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L.S.2.15 / Lassen #1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001399 Genomic DNA. Translation: ACP35412.1.
RefSeq	YP_002832057.1. NC_012589.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	429572.LS215_1404.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACP35412; ACP35412; LS215_1404.
GeneID	7797922.
KEGG	sis:LS215_1404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1059.
HOGENOM	HOG000224507.
KO	K03653.
OMA	IIDRHIL.
ProtClustDB	PRK01229.
Enzyme and pathway databases
BioCyc	SISL429572:GHOW-1448-MONOMER.
Family and domain databases
Gene3D	1.10.340.30. 1 hit.
HAMAP	MF_00241. Ogg.
InterPro	IPR012092. DNA_glyclase/DNA_lyase_thermo. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. [Graphical view]
Pfam	PF00730. HhH-GPD. 1 hit. [Graphical view]
PIRSF	PIRSF005954. Thrmst_ogg. 1 hit.
SMART	SM00478. ENDO3c. 1 hit. [Graphical view]
SUPFAM	SSF48150. DNA_glycsylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OGG1_SULIL

Accession

Primary (citable) accession number: C3MPU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program