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C3MPT6

- GCSPB_SULIL

UniProt

C3MPT6 - GCSPB_SULIL

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, LS215_1391
Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSISL429572:GHOW-1436-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:LS215_1391
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001747: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000212675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi429572.LS215_1391.

Structurei

3D structure databases

ProteinModelPortaliC3MPT6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MPT6-1 [UniParc]FASTAAdd to Basket

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MVWRQAKWDE PLIFELNNSG ANRQGLLINK DDEIRSEIKE MKIPKNLLRE    50
NGPNLPSLSE LEVVRHFIRL SQMNFGVDVG IMPLGSCTMK YNPKIEEKAT 100
AITESHHPLE DEDHVQGILE MIYELQNWFS EITGMDECSL QVPAGSAGEF 150
AGVLMIKKYH EDHNRNYKDT MLVADTAHGT NPASAAMAGY KVMYVKSNGE 200
GLVDMDILRE IVNDKTAGFM LTNPNTLGLF EENILEISKI IHSANAILYY 250
DGANLNGVLG IARPGDMGFD IVHLNLHKTF AVPHGGGGPG AGAICAKGEL 300
VNYLPYPMVE KVNGKYRLSK IPKNSVGKIA TFYGNVGNLA RSFAYLLGLG 350
PQGVQMVGKM STLATNYLIA KLRDIKELEL IAPNRHRKHE VVFSVKQLME 400
NYGVSANDVA KALLDSGFYA PTIYFPPIIE EALMIEPTET ESKETLDMFA 450
EALKKIVEDA KRNPEQLLKS PSNTSIARLD QAYANHPSTI TPTYRVLKLR 500
RMGKINYLK 509
Length:509
Mass (Da):56,584
Last modified:June 16, 2009 - v1
Checksum:i2181A9B4FA39ABD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001399 Genomic DNA. Translation: ACP35399.1.
RefSeqiYP_002832044.1. NC_012589.1.

Genome annotation databases

EnsemblBacteriaiACP35399; ACP35399; LS215_1391.
GeneIDi7797909.
KEGGisis:LS215_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001399 Genomic DNA. Translation: ACP35399.1 .
RefSeqi YP_002832044.1. NC_012589.1.

3D structure databases

ProteinModelPortali C3MPT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 429572.LS215_1391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP35399 ; ACP35399 ; LS215_1391 .
GeneIDi 7797909.
KEGGi sis:LS215_1391.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.

Enzyme and pathway databases

BioCyci SISL429572:GHOW-1436-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L.S.2.15 / Lassen #1.

Entry informationi

Entry nameiGCSPB_SULIL
AccessioniPrimary (citable) accession number: C3MPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi