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C3MPT6

- GCSPB_SULIL

UniProt

C3MPT6 - GCSPB_SULIL

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSISL429572:GHOW-1436-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:LS215_1391
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001747: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000212675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi429572.LS215_1391.

Structurei

3D structure databases

ProteinModelPortaliC3MPT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MPT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVWRQAKWDE PLIFELNNSG ANRQGLLINK DDEIRSEIKE MKIPKNLLRE
60 70 80 90 100
NGPNLPSLSE LEVVRHFIRL SQMNFGVDVG IMPLGSCTMK YNPKIEEKAT
110 120 130 140 150
AITESHHPLE DEDHVQGILE MIYELQNWFS EITGMDECSL QVPAGSAGEF
160 170 180 190 200
AGVLMIKKYH EDHNRNYKDT MLVADTAHGT NPASAAMAGY KVMYVKSNGE
210 220 230 240 250
GLVDMDILRE IVNDKTAGFM LTNPNTLGLF EENILEISKI IHSANAILYY
260 270 280 290 300
DGANLNGVLG IARPGDMGFD IVHLNLHKTF AVPHGGGGPG AGAICAKGEL
310 320 330 340 350
VNYLPYPMVE KVNGKYRLSK IPKNSVGKIA TFYGNVGNLA RSFAYLLGLG
360 370 380 390 400
PQGVQMVGKM STLATNYLIA KLRDIKELEL IAPNRHRKHE VVFSVKQLME
410 420 430 440 450
NYGVSANDVA KALLDSGFYA PTIYFPPIIE EALMIEPTET ESKETLDMFA
460 470 480 490 500
EALKKIVEDA KRNPEQLLKS PSNTSIARLD QAYANHPSTI TPTYRVLKLR

RMGKINYLK
Length:509
Mass (Da):56,584
Last modified:June 16, 2009 - v1
Checksum:i2181A9B4FA39ABD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35399.1.
RefSeqiYP_002832044.1. NC_012589.1.

Genome annotation databases

EnsemblBacteriaiACP35399; ACP35399; LS215_1391.
GeneIDi7797909.
KEGGisis:LS215_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35399.1 .
RefSeqi YP_002832044.1. NC_012589.1.

3D structure databases

ProteinModelPortali C3MPT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 429572.LS215_1391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP35399 ; ACP35399 ; LS215_1391 .
GeneIDi 7797909.
KEGGi sis:LS215_1391.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.

Enzyme and pathway databases

BioCyci SISL429572:GHOW-1436-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L.S.2.15 / Lassen #1.

Entry informationi

Entry nameiGCSPB_SULIL
AccessioniPrimary (citable) accession number: C3MPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3