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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD+UniRule annotation

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei285 – 2851NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSISL429572:GHOW-1386-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:LS215_1343
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001747 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Probable deoxyhypusine synthasePRO_1000203446Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228838.
KOiK00809.
OMAiTYEQMVF.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MPN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINREDLLKN PVEDIALSDL EKYSDIVNVF DKIYGFSSEG IVRGSKILKE
60 70 80 90 100
MIKDADLRFL SFTANLVSTG LRGLFADLVK RGYFNIIVTT GGTIDHDLAR
110 120 130 140 150
SFGGVYYKGS FDIDDAMLKD LEIHRLGNVL VPFESYGKVI EEIVRKFLPE
160 170 180 190 200
IAKDKKEIPA YELLWEFGKR ISDSNSILRA AYEKKVPVIV PGIVDGSFGT
210 220 230 240 250
NLFIQSQFLN FKINLFEDMR LIKDLVFSCK KSGALIIGGG ISKHHTIWWN
260 270 280 290 300
QFKDGLDYAV YVTTAQEYDG SLSGAKPREA ISWNKIRPNA KHATIYGDAT
310
IIVPILAASL LS
Length:312
Mass (Da):34,946
Last modified:June 16, 2009 - v1
Checksum:iF47C7C3439B2D6E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35351.1.
RefSeqiWP_012711264.1. NC_012589.1.

Genome annotation databases

EnsemblBacteriaiACP35351; ACP35351; LS215_1343.
GeneIDi8761185.
KEGGisis:LS215_1343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA. Translation: ACP35351.1.
RefSeqiWP_012711264.1. NC_012589.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP35351; ACP35351; LS215_1343.
GeneIDi8761185.
KEGGisis:LS215_1343.

Phylogenomic databases

HOGENOMiHOG000228838.
KOiK00809.
OMAiTYEQMVF.

Enzyme and pathway databases

UniPathwayiUPA00354.
BioCyciSISL429572:GHOW-1386-MONOMER.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHYS_SULIL
AccessioniPrimary (citable) accession number: C3MPN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.