ID   C3MNS5_SULIL            Unreviewed;       825 AA.
AC   C3MNS5;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=malate synthase {ECO:0000256|ARBA:ARBA00012636};
DE            EC=2.3.3.9 {ECO:0000256|ARBA:ARBA00012636};
GN   OrderedLocusNames=LS215_1003 {ECO:0000313|EMBL:ACP35038.1};
OS   Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=429572 {ECO:0000313|EMBL:ACP35038.1, ECO:0000313|Proteomes:UP000001747};
RN   [1] {ECO:0000313|EMBL:ACP35038.1, ECO:0000313|Proteomes:UP000001747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.S.2.15 / Lassen #1 {ECO:0000313|Proteomes:UP000001747};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- SIMILARITY: Belongs to the malate synthase family.
CC       {ECO:0000256|ARBA:ARBA00006394}.
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DR   EMBL; CP001399; ACP35038.1; -; Genomic_DNA.
DR   RefSeq; WP_012713406.1; NC_012589.1.
DR   AlphaFoldDB; C3MNS5; -.
DR   GeneID; 7797507; -.
DR   KEGG; sis:LS215_1003; -.
DR   HOGENOM; CLU_342775_0_0_2; -.
DR   OrthoDB; 24568at2157; -.
DR   Proteomes; UP000001747; Chromosome.
DR   GO; GO:0004474; F:malate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:InterPro.
DR   CDD; cd00480; malate_synt; 1.
DR   Gene3D; 3.20.20.360; Malate synthase, domain 3; 1.
DR   InterPro; IPR011076; Malate_synth_sf.
DR   InterPro; IPR006252; Malate_synthA.
DR   InterPro; IPR001465; Malate_synthase_TIM.
DR   InterPro; IPR046363; MS_N_TIM-barrel_dom.
DR   PANTHER; PTHR42902; MALATE SYNTHASE; 1.
DR   PANTHER; PTHR42902:SF1; MALATE SYNTHASE 1-RELATED; 1.
DR   Pfam; PF01274; MS_TIM-barrel; 1.
DR   SUPFAM; SSF51645; Malate synthase G; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000313|EMBL:ACP35038.1};
KW   Transferase {ECO:0000313|EMBL:ACP35038.1}.
FT   DOMAIN          211..415
FT                   /note="Malate synthase TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01274"
SQ   SEQUENCE   825 AA;  94712 MW;  CD853E920F02B9CB CRC64;
     MSFGLKISEE VYQKYSDLFG EKTINDRIVS VEKLIEELAV EFSDEIRRII NKRRQWLESK
     DPVTSKGAFP SFDEVFVDAD GNKRTFREII QGMIDNFLGV QSKLRWRLNE NVPIPKDAHP
     LNNPGLEITG PWYPLSRAYN QINSDVACVM EDEEDASPAW YIPFGSGKTT ADVWEGRKNV
     KLFLSGKAPN PYYEKGKTYS LNKPRDKWPV IFHRLPGLHL LDFDITLNGK PVPAIIVSAV
     IYTLNNYNSL KSAGSGVYFY LPKTQTPDEA LVIEKILRRI ESKLGLKIGT LKIALLYEEV
     NAGRFFPIIL WIFRERLIKS NNGRWDYLGS LIEMWLQEKV LPDPQNITMT SPNMMAYQKY
     NALMMLLAGA KNGEADSAPV GGMAAVMLYP QTDPFGRNRY NLKALRGMKL DKLRERLIGL
     IFVAEDKVEG KVTLEEVING KVKGKLYDMF RQSWVATKEE AYVEAGSKPL RVSLEELQKI
     IDAPVNYIEV EGTKLPTVDS GLTPEERALF QKLGLINERG KITPWVITKE MINTPEKLLF
     NKELWGGKDL WHSLYDIPEG DITPEHVQHA FYMAANYGFQ LLNGNLAAAI DDYELKQRFM
     NDLATYRIFT SWLWSVINRD ASFTKDGYIK GSKLTKDGVI PAEDVLKVTK GTKIKDIFEK
     LWELHLDWTY EFYKEQDMRA ARKIAETFGK TNNTSTVEEV YKVVSEAYRS GPFREMSAKE
     AAQKLAKILN ADASEIEEEL INLAPRFDRA MAPVIMEILM KQMLYPKYIM NSGKILFILS
     PLDPERRSKV MDSIFSFRKM VEDKVRKGEL DKWVLELYDY VYDNY
//