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Protein

Indolepyruvate oxidoreductase subunit IorA

Gene

LS215_0989

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.UniRule annotation

Catalytic activityi

(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi551Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi554Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi557Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi563Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi581Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi584Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi587Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi591Iron-sulfur 1 (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSISL429572:G1GUX-1000-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Indolepyruvate oxidoreductase subunit IorAUniRule annotation (EC:1.2.7.8UniRule annotation)
Short name:
IORUniRule annotation
Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit alphaUniRule annotation
Gene namesi
Ordered Locus Names:LS215_0989Imported
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)Imported
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001747 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of the IorA and IorB subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3MNR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini542 – 5714Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini572 – 6014Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Phylogenomic databases

HOGENOMiHOG000224871
KOiK00179
OMAiTFLHTGI
OrthoDBiPOG093Z00SP

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017721 Indolepyruvate_Fd_OxRdtase_asu
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit
PIRSFiPIRSF006439 Indolepyruvate_ferr_oxidored, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR03336 IOR_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

C3MNR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELSTTKRV ILGNEAIAFG ALSAGVSIAA GYPGTPSTEI IETLMAYGKI
60 70 80 90 100
YTEWSANEKV AFETAYGAAI NGAFALTTMK HVGLNVAADP LMSSSYTGVE
110 120 130 140 150
GALVIVSADD PSMWSSQNEQ DNRYYGLHAL IPVIEPYDPQ SAHDLTIEAF
160 170 180 190 200
KLSNKVKHPV ILRSTTRIGH IRGPVELKPP SRPILGKLIK DPKRYVLVPE
210 220 230 240 250
NARRNRVEQL KRWEKIEEEV EGLNGLIDND SENLIIASGI SFSYVIDAMK
260 270 280 290 300
ELDIKANVLR LSTPIPIPKR LFLKAVSNSK RVLIVEEGEP IVEYQIKDLL
310 320 330 340 350
YDQGIRVELH GKDLVSRVGE MTLDKVYYAF SKFFGLDLVT EYLEVPQDIP
360 370 380 390 400
PRPPALCPGC PHRSSFIDLK KAITMASFKP NETFISGDIG CYTLGLLPPF
410 420 430 440 450
DTQDSSTDMG SSIGIANGVY RATGNIPIAV IGDSTFFHSG ISALANAVYT
460 470 480 490 500
QTPMLVLVLD NRSTAMTGQQ PSPSKEIDIG EVAKGLGVKY VKYVDPFDVN
510 520 530 540 550
SSIKELSNAL KWVRENKQPA VVIAKRACAL LVMDNVEENN LPKAIVDLEK
560 570 580 590 600
CTGCSICYDY FTCPAIIPRK DKKAEIDNYT CIGCGACIPV CPFKAISLKG
610
NKLEKWDELW LG
Length:612
Mass (Da):67,145
Last modified:June 16, 2009 - v1
Checksum:iECA6A9CBBF11CB37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA Translation: ACP35025.1
RefSeqiWP_012713395.1, NC_012589.1

Genome annotation databases

EnsemblBacteriaiACP35025; ACP35025; LS215_0989
GeneIDi7797493
KEGGisis:LS215_0989

Similar proteinsi

Entry informationi

Entry nameiC3MNR2_SULIL
AccessioniPrimary (citable) accession number: C3MNR2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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