ID   C3MLT3_SULIL            Unreviewed;       666 AA.
AC   C3MLT3;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Acetate/CoA ligase {ECO:0000313|EMBL:ACP36567.1};
DE            EC=6.2.1.1 {ECO:0000313|EMBL:ACP36567.1};
GN   OrderedLocusNames=LS215_2617 {ECO:0000313|EMBL:ACP36567.1};
OS   Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=429572 {ECO:0000313|EMBL:ACP36567.1, ECO:0000313|Proteomes:UP000001747};
RN   [1] {ECO:0000313|EMBL:ACP36567.1, ECO:0000313|Proteomes:UP000001747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.S.2.15 / Lassen #1 {ECO:0000313|Proteomes:UP000001747};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
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DR   EMBL; CP001399; ACP36567.1; -; Genomic_DNA.
DR   RefSeq; WP_012714445.1; NC_012589.1.
DR   AlphaFoldDB; C3MLT3; -.
DR   GeneID; 7796710; -.
DR   KEGG; sis:LS215_2617; -.
DR   HOGENOM; CLU_000022_3_6_2; -.
DR   OrthoDB; 371752at2157; -.
DR   Proteomes; UP000001747; Chromosome.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACP36567.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          28..80
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          85..481
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          542..620
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   666 AA;  75786 MW;  24ACF1F650C34BA0 CRC64;
     MSVTWALPFD QKINPKLNLN RLVSITTYKE IHSQTVKDYK QFWASVASEI DWFKPWEKTL
     DDSNPPFYKW FVGGELNASY LTVDRHVKSW RKNKVAIIWE GEPVDEKGNP KEVRKLTYYD
     LYREVNRVAY LLKEKYGLKK GDAIAIYLPM IPELPIFMLA AARIGVVFTV VFSGFSADAL
     ASRINDAEAK LLITADGGWR RGKVVDLKGI VDKALEKTPT IKDVIVVRRI GNKVNMVEGR
     DKYFDEVIKD IPQNVYVEPE RMKSEDPLYI LYTSGTTGKP KGIVHDIGGY MTLLHATMKW
     VFDIRDDDIY WCTADIGWVT GHSYIVFGPL MEGATEIMYE GALDYPQPDR WVSIIERYGI
     TILYTSPTAI RSFMKYGDNW VKAHITSTVR LMHSVGEPIN PEAWEWLWKL VGREEVPFGS
     TWWMTETGGI LVSHLPGLYL VPMKPGTNGP PILGIEPDVV NEDGKQVNLE ERGYLVIKNP
     WPGMPLTIYK DPERYVKVYW SRFPGMFYVG DYAVKDKDGY FWILGRADEV IKVAGHRLGT
     YELESALIEH PAVAEAAVIG VPDPVKGEVP YAFVILRQGY TPNTQLSQEI LKTVRDKVGP
     IATIDKIFFV GKLPKTRSGK IMRRVVRAVA TRAEVGDITT LEDEASVEEI KKALEEFKAE
     FEKINK
//