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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSISL429572:G1GUX-2247-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:LS215_2196Imported
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)Imported
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001747 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 412tRNA-synt_1cInterPro annotationAdd BLAST313
Domaini415 – 561tRNA-synt_1c_CInterPro annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 88Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 117"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

C3MJN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSELREII YKYALQNAVK HDGKAEAGPV MSKIIAERPE LRSNAKEIVK
60 70 80 90 100
IVKEIIDQVN SLTLEQQIAE IETKYPELLE EKKHEEKKKI LPPLPNVKGQ
110 120 130 140 150
VVTRFAPNPD GPLHLGNARA AILSYEYAKM YNGKFILRFD DTDPKVKRPI
160 170 180 190 200
LDAYDWIKED LKWLGIKWEQ ELYASERLEV YYKYARYLIE KGHAYVDTCD
210 220 230 240 250
SSTFKKFRDS RGKMREPECL HRSSSPESNL ELFEKMLEGM FKEGEAVVRL
260 270 280 290 300
KTNLMDPDPS QIDWVMLRII DTTKNPHPRV GSKYYAWPTY NFASIIDDHE
310 320 330 340 350
LGVTHILRAK EHMSNTEKQR YISEYMGWEF PEVLQFGRLK LEGFMMSKSK
360 370 380 390 400
IRGMLEKGAN RDDPRLPTLA GLRRRGILPD TIKDVIIDVG VKVTDATISF
410 420 430 440 450
ENIAAINRKK LDPVAKRIMF IKDGEEFAIE LPQTLKAKIP LIPSKQEEVD
460 470 480 490 500
RTIIVNSGDK ILIESIDAED GSVLRLMELC NVRVDKRNRK LVFHSKTLDE
510 520 530 540 550
AKKVNARIVQ WVKSDEKVPV IVEKAERDDI KIINGYAERI VKDLEIDEIV
560 570
QFYRFGFVRV DKKDGNMVSV IFSHD
Length:575
Mass (Da):66,461
Last modified:June 16, 2009 - v1
Checksum:iDF1B4DB42FF6BABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA Translation: ACP36183.1
RefSeqiWP_012714145.1, NC_012589.1

Genome annotation databases

EnsemblBacteriaiACP36183; ACP36183; LS215_2196
GeneIDi7798175
KEGGisis:LS215_2196

Similar proteinsi

Entry informationi

Entry nameiC3MJN0_SULIL
AccessioniPrimary (citable) accession number: C3MJN0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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