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C3MJB1

- NADK_SULIL

UniProt

C3MJB1 - NADK_SULIL

Protein

NAD kinase

Gene

nadK

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei50 – 501NADUniRule annotation
    Binding sitei138 – 1381NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi110 – 1112NADUniRule annotation
    Nucleotide bindingi149 – 1546NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSISL429572:GHOW-35-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:LS215_0035
    OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)
    Taxonomic identifieri429572 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001747: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249NAD kinasePRO_1000205427Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi429572.LS215_0035.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000270621.
    KOiK00858.
    OMAiFPRENFL.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3MJB1-1 [UniParc]FASTAAdd to Basket

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    MRVKIVSKPT SQLNNIIEKI KNISTKLGFE VVDKDFDYVI AVGGDGTLLR    50
    AVKQNKPVIA VKAGRRGLLM DVPVDKFEEA LLRLKKGDYE EEEYMLLEMI 100
    YNDKVELGFN EVGILYDRPE AIKVGISFDT ERVSVEGDGV LVSTPQGSSG 150
    WGMSATNSLL YKDLSAIEII FVNPIFYYLR SVVIPPKPLT LRLEDKGYPQ 200
    TARAVVDGEV VTLIKTNQEI TVRVSQRKAK ILRFFKLDLI GEVLHAYHI 249
    Length:249
    Mass (Da):27,978
    Last modified:June 16, 2009 - v1
    Checksum:i8C86C7F578839319
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001399 Genomic DNA. Translation: ACP34189.1.
    RefSeqiYP_002830834.1. NC_012589.1.

    Genome annotation databases

    EnsemblBacteriaiACP34189; ACP34189; LS215_0035.
    GeneIDi7797100.
    KEGGisis:LS215_0035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001399 Genomic DNA. Translation: ACP34189.1 .
    RefSeqi YP_002830834.1. NC_012589.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 429572.LS215_0035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP34189 ; ACP34189 ; LS215_0035 .
    GeneIDi 7797100.
    KEGGi sis:LS215_0035.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000270621.
    KOi K00858.
    OMAi FPRENFL.

    Enzyme and pathway databases

    BioCyci SISL429572:GHOW-35-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L.S.2.15 / Lassen #1.

    Entry informationi

    Entry nameiNADK_SULIL
    AccessioniPrimary (citable) accession number: C3MJB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3