ID   C3MJA9_SULIL            Unreviewed;       570 AA.
AC   C3MJA9;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACP34187.1};
DE            EC=6.2.1.1 {ECO:0000313|EMBL:ACP34187.1};
GN   OrderedLocusNames=LS215_0033 {ECO:0000313|EMBL:ACP34187.1};
OS   Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=429572 {ECO:0000313|EMBL:ACP34187.1, ECO:0000313|Proteomes:UP000001747};
RN   [1] {ECO:0000313|EMBL:ACP34187.1, ECO:0000313|Proteomes:UP000001747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.S.2.15 / Lassen #1 {ECO:0000313|Proteomes:UP000001747};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
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DR   EMBL; CP001399; ACP34187.1; -; Genomic_DNA.
DR   RefSeq; WP_012712719.1; NC_012589.1.
DR   AlphaFoldDB; C3MJA9; -.
DR   GeneID; 84060532; -.
DR   KEGG; sis:LS215_0033; -.
DR   HOGENOM; CLU_000022_3_6_2; -.
DR   OrthoDB; 193284at2157; -.
DR   Proteomes; UP000001747; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACP34187.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        114..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          3..58
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          68..401
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          460..531
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   570 AA;  64667 MW;  84061A808EB15226 CRC64;
     MDYYTLYDLS LEKPETYWET FANKLSFFKK WEKVIEKNKQ LPIAKWFVNG TTNIAYNALN
     HTGKALIFYK EHKYKGDEIT FNELNNMSSM IAGLLLDKGV RRGDRIAIYM PNSIYTIATI
     LAAARIGVIY TLVFAGLGIN AIVSRISNLE PKLVISTDKT FRRGKEIKLY TNLANIIFPR
     DSQFDYPREY KEFEKIESNE PLKIMYTSGT TGKPKGIILP HGAWMVGDYT VFELMFSLKS
     NDIVLTTADV GWITFSRIMY GTLMHGSTLA FIEGAPDYPT DRLPKIIDEL QPKVLFTSPT
     LLRTLQKLDV KLPRVEFIAT AGEIMDETAW KYALRFSDKV VDVYGQTELG YVIGYPYALD
     SVEPKIGYAG LPFPGAVIDT VDEYGKSLRG HVGHLIARGP FPTQFIGIWK DEAKFLSYFE
     KFNGHDTGDL AIINEKGYVK IVGRDDDMIK IAGHRITSGE VESVINSLEG IVESAAVGIP
     DEIKGEKLVV FYVGNIDEKT IVTKVREMLG PIYVIDKIYK VERLPKSRSG KIVRRVLRDL
     LLEKEIDETI LEDPEILKEI KSEIKRSERI
//