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C3MIE5 (BETB_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:NGR_c07000
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandMetal-binding
NAD
NADP
Potassium
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000148557

Regions

Nucleotide binding150 – 1534NAD/NADP By similarity
Nucleotide binding176 – 1794NAD/NADP By similarity
Nucleotide binding228 – 2336NAD/NADP By similarity

Sites

Active site1621Charge relay system By similarity
Active site2501Proton acceptor By similarity
Active site4611Charge relay system By similarity
Metal binding261Potassium 1 By similarity
Metal binding271Potassium 1; via carbonyl oxygen By similarity
Metal binding931Potassium 1 By similarity
Metal binding2441Potassium 2; via carbonyl oxygen By similarity
Metal binding4541Potassium 2; via carbonyl oxygen By similarity
Metal binding4571Potassium 2; via carbonyl oxygen By similarity
Binding site2841NAD/NADP By similarity
Binding site3841NAD/NADP By similarity

Amino acid modifications

Modified residue2841Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
C3MIE5 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 97ACA1FADD8BB118

FASTA48751,748
        10         20         30         40         50         60 
MKAQPKASHF IDGEYVEDTA GTVIESIYPA TGEVIARLHA ATPDIVEKAI AAAKRAQPEW 

        70         80         90        100        110        120 
AAMSPTARGR ILKRAAEIMR ERNRELSELE TLDTGKPIQE TIVADPTSGA DSFEFFGGIA 

       130        140        150        160        170        180 
AAALNGDYIP LGGDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALAAG NSMVFKPSEN 

       190        200        210        220        230        240 
TPLGALKIAE ILIEAGLPKG LYNVIQGDRS TGPLLVNHPD VAKVSLTGSV PTGKKVAAAA 

       250        260        270        280        290        300 
AAELKHVTME LGGKSPLIVF DDADLESAIG GAMLGNFYST GQVCSNGTRV FVQRKIKDAF 

       310        320        330        340        350        360 
LARLKERTEA IVIGDPMDEA TQLGPMVSKA QRDKVLSYIE QGKAEGARLV TGGGIPNAVN 

       370        380        390        400        410        420 
TEGTYIQPTV FADVTDEMTI AREEIFGPVM CVLDFDDEAE VVARANATEF GLSAGVFTAD 

       430        440        450        460        470        480 
LTRAHRVVDQ LEAGTLWINT YNLAPVEIPF GGSKQSGFGR ENSVAALNHY TELKTVYVGM 


GKVEAPY 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP24493.1.
RefSeqYP_002825246.1. NC_012587.1.

3D structure databases

ProteinModelPortalC3MIE5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c07000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP24493; ACP24493; NGR_c07000.
GeneID7791926.
KEGGrhi:NGR_c07000.
PATRIC32307783. VBIRhiSp122450_3515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMACEHQLVA.
OrthoDBEOG6BS8QW.

Enzyme and pathway databases

BioCycSFRE394:GBYN-699-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHISN
AccessionPrimary (citable) accession number: C3MIE5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways