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C3MIE5 (BETB_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:NGR_c07000
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium ›

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000148557

Regions

Nucleotide binding228 – 2336NAD By similarity

Sites

Active site2501 By similarity
Active site2841 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3MIE5 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 97ACA1FADD8BB118

FASTA48751,748
        10         20         30         40         50         60 
MKAQPKASHF IDGEYVEDTA GTVIESIYPA TGEVIARLHA ATPDIVEKAI AAAKRAQPEW 

        70         80         90        100        110        120 
AAMSPTARGR ILKRAAEIMR ERNRELSELE TLDTGKPIQE TIVADPTSGA DSFEFFGGIA 

       130        140        150        160        170        180 
AAALNGDYIP LGGDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALAAG NSMVFKPSEN 

       190        200        210        220        230        240 
TPLGALKIAE ILIEAGLPKG LYNVIQGDRS TGPLLVNHPD VAKVSLTGSV PTGKKVAAAA 

       250        260        270        280        290        300 
AAELKHVTME LGGKSPLIVF DDADLESAIG GAMLGNFYST GQVCSNGTRV FVQRKIKDAF 

       310        320        330        340        350        360 
LARLKERTEA IVIGDPMDEA TQLGPMVSKA QRDKVLSYIE QGKAEGARLV TGGGIPNAVN 

       370        380        390        400        410        420 
TEGTYIQPTV FADVTDEMTI AREEIFGPVM CVLDFDDEAE VVARANATEF GLSAGVFTAD 

       430        440        450        460        470        480 
LTRAHRVVDQ LEAGTLWINT YNLAPVEIPF GGSKQSGFGR ENSVAALNHY TELKTVYVGM 


GKVEAPY

« Hide

References

[1]"Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems."
Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A., Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A., Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A., Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.
Appl. Environ. Microbiol. 75:4035-4045(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NGR234.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001389 Genomic DNA. Translation: ACP24493.1.
RefSeqYP_002825246.1. NC_012587.1.

3D structure databases

ProteinModelPortalC3MIE5.
ModBaseSearch...

Protein-protein interaction databases

STRING394.NGR_c07000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP24493; ACP24493; NGR_c07000.
GeneID7791926.
KEGGrhi:NGR_c07000.
PATRIC32307783. VBIRhiSp122450_3515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAIMRERNR.
ProtClustDBPRK13252.

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHISN
AccessionPrimary (citable) accession number: C3MIE5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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