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C3MIE4

- BETA_RHISN

UniProt

C3MIE4 - BETA_RHISN

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, NGR_c06990
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSFRE394:GBYN-698-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:NGR_c06990
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000148352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c06990.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3MIE4-1 [UniParc]FASTAAdd to Basket

« Hide

MQADYIIIGS GSAGSALAHR LSEDSRNSVI VLEFGGTDIG PFIQMPAALA    50
WPMSMNRYNW GYLSEPEPHL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE 100
DFDRWEQLGA KGWAYADVLP YFKRMEHSHG GEDGWRGTDG PLHVQRGPVK 150
NPLFHAFVEA GKQAGFEMTD DYNGSKQEGF GLMEQTTWRG RRWSAASAYL 200
KPALKRPNVQ LIRCFARKIV IENGRATGVE IERGGRIEVV KANREVIVSA 250
SSFNSPKLLM LSGIGPAAHL KDLGIDVKVD RPGVGQNLQD HMEFYFQQIS 300
TKPVSLYSWL PWFWQGVAGA QWLFFKSGLG ISNQFEACAF LRSAPGVKQP 350
DIQYHFLPVA IRYDGKAAAN THGFQVHVGY NLSKSRGSVT LRASDPKADP 400
VIRFNYMSHP EDWEKFRHCV RLTREIFGQK AFDQYRGPEI QPGERVQTDE 450
EIDAFLREHL ESAYHPCGTC KMGSKDDPMA VVDPETRVIG VDGLRVADSS 500
IFPHVTYGNL NAPSIMTGEK AADHILGKQP LARSNQEPWI NPRWAISDR 549
Length:549
Mass (Da):61,270
Last modified:June 16, 2009 - v1
Checksum:i79D2264C2A38454D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP24492.1.
RefSeqiYP_002825245.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP24492; ACP24492; NGR_c06990.
GeneIDi7791925.
KEGGirhi:NGR_c06990.
PATRICi32307779. VBIRhiSp122450_3513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP24492.1 .
RefSeqi YP_002825245.1. NC_012587.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 394.NGR_c06990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP24492 ; ACP24492 ; NGR_c06990 .
GeneIDi 7791925.
KEGGi rhi:NGR_c06990.
PATRICi 32307779. VBIRhiSp122450_3513.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SFRE394:GBYN-698-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiBETA_RHISN
AccessioniPrimary (citable) accession number: C3MIE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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