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C3MIE4

- BETA_RHISN

UniProt

C3MIE4 - BETA_RHISN

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSFRE394:GBYN-698-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:NGR_c06990
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000148352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c06990.

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3MIE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQADYIIIGS GSAGSALAHR LSEDSRNSVI VLEFGGTDIG PFIQMPAALA
60 70 80 90 100
WPMSMNRYNW GYLSEPEPHL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE
110 120 130 140 150
DFDRWEQLGA KGWAYADVLP YFKRMEHSHG GEDGWRGTDG PLHVQRGPVK
160 170 180 190 200
NPLFHAFVEA GKQAGFEMTD DYNGSKQEGF GLMEQTTWRG RRWSAASAYL
210 220 230 240 250
KPALKRPNVQ LIRCFARKIV IENGRATGVE IERGGRIEVV KANREVIVSA
260 270 280 290 300
SSFNSPKLLM LSGIGPAAHL KDLGIDVKVD RPGVGQNLQD HMEFYFQQIS
310 320 330 340 350
TKPVSLYSWL PWFWQGVAGA QWLFFKSGLG ISNQFEACAF LRSAPGVKQP
360 370 380 390 400
DIQYHFLPVA IRYDGKAAAN THGFQVHVGY NLSKSRGSVT LRASDPKADP
410 420 430 440 450
VIRFNYMSHP EDWEKFRHCV RLTREIFGQK AFDQYRGPEI QPGERVQTDE
460 470 480 490 500
EIDAFLREHL ESAYHPCGTC KMGSKDDPMA VVDPETRVIG VDGLRVADSS
510 520 530 540
IFPHVTYGNL NAPSIMTGEK AADHILGKQP LARSNQEPWI NPRWAISDR
Length:549
Mass (Da):61,270
Last modified:June 16, 2009 - v1
Checksum:i79D2264C2A38454D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP24492.1.
RefSeqiWP_012707277.1. NC_012587.1.
YP_002825245.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP24492; ACP24492; NGR_c06990.
GeneIDi7791925.
KEGGirhi:NGR_c06990.
PATRICi32307779. VBIRhiSp122450_3513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP24492.1 .
RefSeqi WP_012707277.1. NC_012587.1.
YP_002825245.1. NC_012587.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_c06990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP24492 ; ACP24492 ; NGR_c06990 .
GeneIDi 7791925.
KEGGi rhi:NGR_c06990.
PATRICi 32307779. VBIRhiSp122450_3513.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SFRE394:GBYN-698-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiBETA_RHISN
AccessioniPrimary (citable) accession number: C3MIE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3