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C3MIE4 (BETA_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:NGR_c06990
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000148352

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4651 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3MIE4 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 79D2264C2A38454D

FASTA54961,270
        10         20         30         40         50         60 
MQADYIIIGS GSAGSALAHR LSEDSRNSVI VLEFGGTDIG PFIQMPAALA WPMSMNRYNW 

        70         80         90        100        110        120 
GYLSEPEPHL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE DFDRWEQLGA KGWAYADVLP 

       130        140        150        160        170        180 
YFKRMEHSHG GEDGWRGTDG PLHVQRGPVK NPLFHAFVEA GKQAGFEMTD DYNGSKQEGF 

       190        200        210        220        230        240 
GLMEQTTWRG RRWSAASAYL KPALKRPNVQ LIRCFARKIV IENGRATGVE IERGGRIEVV 

       250        260        270        280        290        300 
KANREVIVSA SSFNSPKLLM LSGIGPAAHL KDLGIDVKVD RPGVGQNLQD HMEFYFQQIS 

       310        320        330        340        350        360 
TKPVSLYSWL PWFWQGVAGA QWLFFKSGLG ISNQFEACAF LRSAPGVKQP DIQYHFLPVA 

       370        380        390        400        410        420 
IRYDGKAAAN THGFQVHVGY NLSKSRGSVT LRASDPKADP VIRFNYMSHP EDWEKFRHCV 

       430        440        450        460        470        480 
RLTREIFGQK AFDQYRGPEI QPGERVQTDE EIDAFLREHL ESAYHPCGTC KMGSKDDPMA 

       490        500        510        520        530        540 
VVDPETRVIG VDGLRVADSS IFPHVTYGNL NAPSIMTGEK AADHILGKQP LARSNQEPWI 


NPRWAISDR 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP24492.1.
RefSeqYP_002825245.1. NC_012587.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c06990.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP24492; ACP24492; NGR_c06990.
GeneID7791925.
KEGGrhi:NGR_c06990.
PATRIC32307779. VBIRhiSp122450_3513.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycSFRE394:GBYN-698-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_RHISN
AccessionPrimary (citable) accession number: C3MIE4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways