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C3MI21 (C3MI21_RHISN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH HAMAP-Rule MF_01458 EMBL ACP26523.1
Ordered Locus Names:NGR_c27760 EMBL ACP26523.1
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP] EMBL ACP26523.1
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium ›

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Topological domain1 – 77Cytoplasmic By similarity HAMAP-Rule MF_01458
Transmembrane8 – 2821Helical; By similarity HAMAP-Rule MF_01458
Topological domain29 – 10577Periplasmic By similarity HAMAP-Rule MF_01458
Transmembrane106 – 12621Helical; By similarity HAMAP-Rule MF_01458
Topological domain127 – 645519Cytoplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding198 – 2058ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4211 By similarity HAMAP-Rule MF_01458
Metal binding4201Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4241Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4981Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
C3MI21 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 86ADEF439AC60BFF

FASTA64570,494
        10         20         30         40         50         60 
MNPNFRNFAL WAIIALLLIA LFSMFQQPTE RTGSREIPFS QFLKDVDASR VKEVVITGSK 

        70         80         90        100        110        120 
VIGSYTESGA TFQTYAPAVD TALTERLEAK DVTVTVRPET DGSSGFLSYI GTLLPMLLIL 

       130        140        150        160        170        180 
GVWLFFMRQM QGGSRGAMGF GKSKAKLLTE AHGRVTFDDV AGVDEAKQDL EEIVEFLRDP 

       190        200        210        220        230        240 
QKFQRLGGRI PRGVLLVGPP GTGKTLLARS VAGEANVPFF TISGSDFVEM FVGVGASRVR 

       250        260        270        280        290        300 
DMFEQAKKNA PCIIFIDEID AVGRHRGAGL GGGNDEREQT LNQLLVEMDG FEANEGIILI 

       310        320        330        340        350        360 
AATNRPDVLD PALLRPGRFD RQVVVPNPDI NGRERILKVH VRNVPLAPNV DLKVLARGTP 

       370        380        390        400        410        420 
GFSGADLMNL VNEAALMAAR RNKRLVTMQE FEDAKDKIMM GAERRSSAMT EAEKKLTAYH 

       430        440        450        460        470        480 
EAGHAIVALN VPSADPLHKA TIIPRGRALG MVMQLPEGDR YSMSYKWMIS RLAIMMGGRV 

       490        500        510        520        530        540 
AEELTFGKEN ITSGASSDIE QATKLARAMV TQWGFSDQLG QVAYGENQQE VFLGHSVAQQ 

       550        560        570        580        590        600 
KNVSEATAQK IDNEIRRLID DAYEAARSIL TEKHHEFVAL AEGLLEYETL TGDEIKALIR 

       610        620        630        640 
GEKPARDLGD DTPPHRGSAV PSAGTKKEVG NKGEEPEGGF EPQPQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001389 Genomic DNA. Translation: ACP26523.1.
RefSeqYP_002827276.1. NC_012587.1.

3D structure databases

ProteinModelPortalC3MI21.
ModBaseSearch...

Protein-protein interaction databases

STRING394.NGR_c27760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP26523; ACP26523; NGR_c27760.
GeneID7790430.
KEGGrhi:NGR_c27760.
PATRIC32312041. VBIRhiSp122450_5610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0465.
HOGENOMHOG000217276.
KOK03798.
OMATGKADDE.
ProtClustDBCLSK863899.

Family and domain databases

HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3MI21_RHISN
AccessionPrimary (citable) accession number: C3MI21
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info