C3MFW1 (PNCB_RHISN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	NGR_c02120

Organism

Rhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]

Taxonomic identifier

394 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium › Sinorhizobium fredii group › Rhizobium fredii

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000191531

Sequences

	Sequence		Length	Mass (Da)
	C3MFW1 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 462B82671F27648C	FASTA	434	49,809
	10 20 30 40 50 60 MPKTDIARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWQ LYPDVDATFS LINRTKTVRL 70 80 90 100 110 120 AEEIDEQELR DQLDHARTLR FSKKEMIWLA GNTFYGRKQI FSPEFLSWLA RFRLPEYELS 130 140 150 160 170 180 RRDGQFELTF RGRWVETTMW EIPALAIINE LRSRAAMKGL GPFTLDVLYA RAKAKMWSKV 190 200 210 220 230 240 EQLRQYPNLR ISDFGTRRRH SFLWQRWCVE ALKEGIGASF SGSSNVLLAM DNDLEALGTN 250 260 270 280 290 300 AHELPMVAAA LARNDKELAA APYKVLQDWN QLYGGNLLIV LPDSFGTAAF LRNAPDWVAD 310 320 330 340 350 360 WTGFRPDSAP PVEGGEKILA WWKKKGRDPR DKLLIFSDGL DVDTIIKTYR HFEGRVRMSF 370 380 390 400 410 420 GWGTNLTNDF AGCAPTEIGG LNPISIVCKV SEANGRPAVK LSDNPRKATG DPAEVERYLK 430 FFGTEDFVEQ TVRV

References

[1]

"Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems." Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A., Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A., Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A., Broughton W.J., Perret X., Strittmatter A.W., Streit W.R. Appl. Environ. Microbiol. 75:4035-4045(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NGR234.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001389 Genomic DNA. Translation: ACP24012.1.
RefSeq	YP_002824765.1. NC_012587.1.
3D structure databases
ProteinModelPortal	C3MFW1.
ModBase	Search...
Protein-protein interaction databases
STRING	394.NGR_c02120.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACP24012; ACP24012; NGR_c02120.
GeneID	7790790.
KEGG	rhi:NGR_c02120.
PATRIC	32306764. VBIRhiSp122450_3012.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284929.
KO	K00763.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_RHISN

Accession

Primary (citable) accession number: C3MFW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program