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C3MFQ8

- FTHS_RHISN

UniProt

C3MFQ8 - FTHS_RHISN

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, NGR_c23560
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRE394:GBYN-2349-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:NGR_c23560
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000185260Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c23560.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3MFQ8-1 [UniParc]FASTAAdd to Basket

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MPEVKSDIEI ARAARKQPIM EIGAKLGIPP EHLLPYGHDK AKVSAEFIAA    50
QKTNGNGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KTIVCIREAS 100
LGPCFGIKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLAALIDNH 150
IYWGNEQAID IRRIAWRRVM DMNDRALRQI IGSLGGVANG YPRETGFDIT 200
VASEVMAILC LAADIRDLEK RLGNIIIGYR RDKSPVYARD IKADGAMAVL 250
LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
EAGFGADLGA EKFFDIKCRK AGLKPDAAVV VATVRAIKMN GGVKKDDLGK 350
ENLEALRKGC ANLGRHVQNV KKFGVPVLVA INHFTSDTEA EIQAIKDYVR 400
TLGSEAVLCR HWAEGSAGIE ELAHKVVDLA NAGHSQFSPL YPDDMPLFHK 450
IETIAKDIYH ASEVIADKLV RDQLRTWEDQ GYGHLPICMA KTQYSFSTDP 500
NLRGAPSGHA VPIREVRLAA GAGFVVVITG EIMTMPGLPK VPSSEKIRLN 550
EAGYIEGLF 559
Length:559
Mass (Da):60,212
Last modified:June 16, 2009 - v1
Checksum:i9CE6899189AAC085
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP26115.1.
RefSeqiWP_012708873.1. NC_012587.1.
YP_002826868.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP26115; ACP26115; NGR_c23560.
GeneIDi7790012.
KEGGirhi:NGR_c23560.
PATRICi32311153. VBIRhiSp122450_5175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP26115.1 .
RefSeqi WP_012708873.1. NC_012587.1.
YP_002826868.1. NC_012587.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_c23560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP26115 ; ACP26115 ; NGR_c23560 .
GeneIDi 7790012.
KEGGi rhi:NGR_c23560.
PATRICi 32311153. VBIRhiSp122450_5175.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SFRE394:GBYN-2349-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiFTHS_RHISN
AccessioniPrimary (citable) accession number: C3MFQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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