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C3MFQ8

- FTHS_RHISN

UniProt

C3MFQ8 - FTHS_RHISN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFRE394:GBYN-2349-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:NGR_c23560
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_1000185260Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi394.NGR_c23560.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3MFQ8-1 [UniParc]FASTAAdd to Basket

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    MPEVKSDIEI ARAARKQPIM EIGAKLGIPP EHLLPYGHDK AKVSAEFIAA    50
    QKTNGNGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KTIVCIREAS 100
    LGPCFGIKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLAALIDNH 150
    IYWGNEQAID IRRIAWRRVM DMNDRALRQI IGSLGGVANG YPRETGFDIT 200
    VASEVMAILC LAADIRDLEK RLGNIIIGYR RDKSPVYARD IKADGAMAVL 250
    LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
    EAGFGADLGA EKFFDIKCRK AGLKPDAAVV VATVRAIKMN GGVKKDDLGK 350
    ENLEALRKGC ANLGRHVQNV KKFGVPVLVA INHFTSDTEA EIQAIKDYVR 400
    TLGSEAVLCR HWAEGSAGIE ELAHKVVDLA NAGHSQFSPL YPDDMPLFHK 450
    IETIAKDIYH ASEVIADKLV RDQLRTWEDQ GYGHLPICMA KTQYSFSTDP 500
    NLRGAPSGHA VPIREVRLAA GAGFVVVITG EIMTMPGLPK VPSSEKIRLN 550
    EAGYIEGLF 559
    Length:559
    Mass (Da):60,212
    Last modified:June 16, 2009 - v1
    Checksum:i9CE6899189AAC085
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP26115.1.
    RefSeqiWP_012708873.1. NC_012587.1.
    YP_002826868.1. NC_012587.1.

    Genome annotation databases

    EnsemblBacteriaiACP26115; ACP26115; NGR_c23560.
    GeneIDi7790012.
    KEGGirhi:NGR_c23560.
    PATRICi32311153. VBIRhiSp122450_5175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP26115.1 .
    RefSeqi WP_012708873.1. NC_012587.1.
    YP_002826868.1. NC_012587.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_c23560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP26115 ; ACP26115 ; NGR_c23560 .
    GeneIDi 7790012.
    KEGGi rhi:NGR_c23560.
    PATRICi 32311153. VBIRhiSp122450_5175.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SFRE394:GBYN-2349-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiFTHS_RHISN
    AccessioniPrimary (citable) accession number: C3MFQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3