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C3MD89 (C3MD89_RHISN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL ACP25408.1
Ordered Locus Names:NGR_c16430 EMBL ACP25408.1
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP] EMBL ACP25408.1
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity
Site2101Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
C3MD89 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: CAB24B37A4E743EF

FASTA40445,282
        10         20         30         40         50         60 
MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDLDLE YYDLSVENRD ATEDQVTIDA 

        70         80         90        100        110        120 
ANAIKEHGVG VKCATITPDE ARVEEFSLKK MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTKPIIV GRHAFGDQYR ATDFKFPGKG KLTMKFVGED GKEIEYDVFD APSAGVAMGM 

       190        200        210        220        230        240 
YNLDDSITEF ARASFNYGLQ RKVPVYLSTK NTILKVYDGR FKDIFQKVFD EEFAEQFKAA 

       250        260        270        280        290        300 
KLWYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDGNSEL AKFSDTLERV 

       370        380        390        400 
CVETVEAGFM TKDLALLIGP DQPWLSTTGF LDKIDENLKK AMAA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP25408.1.
RefSeqYP_002826161.1. NC_012587.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c16430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP25408; ACP25408; NGR_c16430.
GeneID7790923.
KEGGrhi:NGR_c16430.
PATRIC32309717. VBIRhiSp122450_4459.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycSFRE394:GBYN-1640-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3MD89_RHISN
AccessionPrimary (citable) accession number: C3MD89
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)