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Protein

Glutaminase

Gene

glsA

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701SubstrateUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Binding sitei249 – 2491SubstrateUniRule annotation
Binding sitei267 – 2671Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSFRE394:GBYN-1632-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:NGR_c16350
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315GlutaminasePRO_1000132910Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi394.NGR_c16350.

Structurei

3D structure databases

ProteinModelPortaliC3MD81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MD81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQKAPQDL QLILDDIYRE LTPRLGEGKV ADYIPQLARV NPQHFGMAIV
60 70 80 90 100
TTGGEVHRVG DAEVPFSIQS ISKVFTLTLA LGKHGENIWH RVGREPSGSA
110 120 130 140 150
FNSIVQLEHE GGKPRNPFIN AGAITISDLI LAGHTPKELI GEIVRFVRYL
160 170 180 190 200
ADDENIVIDH EVARSETVTG FRNFALASFM RSFGRLDHPV EHVLGVYFHH
210 220 230 240 250
CALAMTCSQL AKAGLFLAAG GTNPLTGHSV VSRQRARRIN ALMLTCGHYD
260 270 280 290 300
GSGDFAYRVG LPGKSGVGGG IMAVAPGKAS IAVWSPGLNE NGNSLLGSLA
310
LEMLAARTGW SVFGP
Length:315
Mass (Da):33,838
Last modified:June 16, 2009 - v1
Checksum:i7C0303E270407796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001389 Genomic DNA. Translation: ACP25400.1.
RefSeqiWP_012708169.1. NC_012587.1.
YP_002826153.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP25400; ACP25400; NGR_c16350.
GeneIDi7790915.
KEGGirhi:NGR_c16350.
PATRICi32309701. VBIRhiSp122450_4451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001389 Genomic DNA. Translation: ACP25400.1.
RefSeqiWP_012708169.1. NC_012587.1.
YP_002826153.1. NC_012587.1.

3D structure databases

ProteinModelPortaliC3MD81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi394.NGR_c16350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP25400; ACP25400; NGR_c16350.
GeneIDi7790915.
KEGGirhi:NGR_c16350.
PATRICi32309701. VBIRhiSp122450_4451.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciSFRE394:GBYN-1632-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiGLSA_RHISN
AccessioniPrimary (citable) accession number: C3MD81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: April 29, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.