Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C3MBH0 (TYPH_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:NGR_c34550
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000186264

Sequences

Sequence LengthMass (Da)Tools
C3MBH0 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: E05614750BF93B43

FASTA43846,265
        10         20         30         40         50         60 
MALLPQEVIR KKRDGGRLDR AEIADFVSGL ADGSISEGQV AAFAMATWFS GMNRDECVAL 

        70         80         90        100        110        120 
TLAMRDSGDI LDWSEFGRPI VDKHSTGGVG DNVSLMLAPI VAACGPNVPM ISGRGLGHTG 

       130        140        150        160        170        180 
GTLDKLESIP GYNIQPSPEL FRQIVDEVGC AIIGQTANLA PADKRLYAIR DVTATVDSVP 

       190        200        210        220        230        240 
LITASILSKK LAAGLQSLVL DVKLGNGSFM TDARATKTLA RSLVDVANGA GVNTLALITD 

       250        260        270        280        290        300 
MNEPLADAVG NALEVENCLA YLRGEKSGTR LDQVVMAFAA EMLVAARMAA HPAAGEAMAR 

       310        320        330        340        350        360 
QALESGDAME RFALMVHRLG GPADFVDRSE AYLEKAPAVV IVPANRDGYL AACETRELGM 

       370        380        390        400        410        420 
AVIALGGGRT RPDDRIDHRV GLAGLKPLGT KVERGEPIAF VHAADRQQAE AVRDRIAGFY 

       430 
AIADERPASR PVIVSRIT 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP27179.1.
RefSeqYP_002827932.1. NC_012587.1.

3D structure databases

ProteinModelPortalC3MBH0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c34550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP27179; ACP27179; NGR_c34550.
GeneID7792722.
KEGGrhi:NGR_c34550.
PATRIC32313457. VBIRhiSp122450_6302.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMAHYRITED.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-201-MONOMER.
SFRE394:GBYN-3439-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_RHISN
AccessionPrimary (citable) accession number: C3MBH0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways