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C3MBD2

- MASZ_RHISN

UniProt

C3MBD2 - MASZ_RHISN

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Protein

Malate synthase G

Gene

glcB

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei274 – 2741Acetyl-CoAUniRule annotation
Binding sitei311 – 3111Acetyl-CoAUniRule annotation
Active sitei338 – 3381Proton acceptorUniRule annotation
Binding sitei338 – 3381GlyoxylateUniRule annotation
Metal bindingi430 – 4301MagnesiumUniRule annotation
Binding sitei430 – 4301GlyoxylateUniRule annotation
Metal bindingi458 – 4581MagnesiumUniRule annotation
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei629 – 6291Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSFRE394:GBYN-3395-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:NGR_c34110
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GPRO_1000147427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi394.NGR_c34110.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA bindingUniRule annotation
Regioni455 – 4584Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MBD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRVEKHDLK IDAGLHRFLV DEAMPGTGID PEHFFAALSA LVHDLAPKNR
60 70 80 90 100
ALLARRDELQ AKLDAWYREH GAPVDLDAYQ AFLKEIGYLL PEGPDFSVST
110 120 130 140 150
ANVDAEIATI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIPDAD
160 170 180 190 200
GGTRGRSYNP ARGAKVIAWA RDFLDASVPL AAGRWSDVGG LAIDGTALSL
210 220 230 240 250
TLTNGTKTTL RNPAQFAGYS GSAEAPSQIV LRQNNLHVVI VLDATTPIGQ
260 270 280 290 300
ADPAGISDII LESAITTIMD CEDSVAAVDA EDKVVVYRNW LGLMKGDLAE
310 320 330 340 350
EVAKGGRTFT RKLNADRVFT RPNGETLTLP GRALMLVRNV GHLMTNPAIL
360 370 380 390 400
DRDGREVPEG LMDAMVTALI ALHDIGANGR RANSRAGSMY VVKPKMHGPE
410 420 430 440 450
EVAFACEIFS HVEAALGLPE NTIKMGIMDE ERRTTVNLKE CIRAARDRVV
460 470 480 490 500
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QAAWIGAYEN WNVDIGLECG
510 520 530 540 550
LSGRAQIGKG MWAMPDLMAA MLEQKIAHPK AGANTAWVPS PTAATLHATH
560 570 580 590 600
YHRVDVAEVQ AGLGSRPRAR LADILSVPVA ARPNWTEEEI QRELDNNAQG
610 620 630 640 650
ILGYVVRWVD EGVGCSKVPD INNVGLMEDR ATLRISAQHM ANWLHHGIVS
660 670 680 690 700
KVQIVETMKR MAEIVDRQNA GDPSYVPMAG RLEQSIAFQA ALDLVLKGRE
710 720
QPNGYTEPVL HRRRLELKAK QRAS
Length:724
Mass (Da):78,795
Last modified:June 16, 2009 - v1
Checksum:iD90D8C146A321A1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27141.1.
RefSeqiWP_012709888.1. NC_012587.1.
YP_002827894.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP27141; ACP27141; NGR_c34110.
GeneIDi7792678.
KEGGirhi:NGR_c34110.
PATRICi32313365. VBIRhiSp122450_6262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27141.1 .
RefSeqi WP_012709888.1. NC_012587.1.
YP_002827894.1. NC_012587.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_c34110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP27141 ; ACP27141 ; NGR_c34110 .
GeneIDi 7792678.
KEGGi rhi:NGR_c34110.
PATRICi 32313365. VBIRhiSp122450_6262.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci SFRE394:GBYN-3395-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiMASZ_RHISN
AccessioniPrimary (citable) accession number: C3MBD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3