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C3MB60

- SYL_RHISN

UniProt

C3MB60 - SYL_RHISN

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Protein
Leucine--tRNA ligase
Gene
leuS, NGR_c33390
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRE394:GBYN-3323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NGR_c33390
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Leucine--tRNA ligaseUniRule annotation
PRO_1000199220Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c33390.

Structurei

3D structure databases

ProteinModelPortaliC3MB60.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi632 – 6365"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3MB60-1 [UniParc]FASTAAdd to Basket

« Hide

MATERYNPRD TEPRWQQEWD ARKVFETEND DPREKYYVLE MFPYPSGRIH    50
MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAG 100
WTYQNIAAMK AQLKVMGLSL DWSREFATCD PAYYQRQQYL FLDFLEKGLV 150
YRRQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS 200
QDLLDALDGL EQWPEKVRLM QKNWIGRSEG LALRWALDPA TVPGETKELT 250
VYTTRPDTLF GASFLAISAD HPLAREAAAK DAAIDAFCEE CRRAGTSLAA 300
LETAEKKGID TGIRARHPFD PEWELPVYVA NFVLMDYGTG AIFGCPSGDQ 350
RDLDFARKYG LSVVPVVMPK DADAATFTIE DEAYGGDGVM INSRFLDGLS 400
TEEAFEAVAS KLEQETLDGA PRAERKVNFR LRDWGISRQR YWGCPIPVIH 450
CEDCGVVPVP KADLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR 500
RETDTMDTFV DSSWYYARFT APWEDKPTDP KAANHWLPVD QYIGGIEHAI 550
LHLLYSRFFT RAMKATGHVA MDEPFKGLFT QGMVVHETYS RGEGAQREWV 600
TPAEIRIDEI DGRRRAVLIE TGEEVAIGSI EKMSKSKKNV VDPDDIIGSY 650
GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLV GEAAESLRGA 700
KASPAKEGEG LAISQAAHRT LRAVEADYDK LAFNKAVARI YELVNVLAAP 750
LTQVAAGKAD QAVTAAVKDA TTILIDLIAP MMPHLAEECW REIGGEGLIA 800
ERPWPTFDPA LVVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD 850
AVKAALNGAS PRKIIVVPQR IVNVVV 876
Length:876
Mass (Da):97,961
Last modified:June 16, 2009 - v1
Checksum:i247F386ACAF60FEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27069.1.
RefSeqiYP_002827822.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP27069; ACP27069; NGR_c33390.
GeneIDi7792606.
KEGGirhi:NGR_c33390.
PATRICi32313209. VBIRhiSp122450_6184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27069.1 .
RefSeqi YP_002827822.1. NC_012587.1.

3D structure databases

ProteinModelPortali C3MB60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_c33390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP27069 ; ACP27069 ; NGR_c33390 .
GeneIDi 7792606.
KEGGi rhi:NGR_c33390.
PATRICi 32313209. VBIRhiSp122450_6184.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SFRE394:GBYN-3323-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiSYL_RHISN
AccessioniPrimary (citable) accession number: C3MB60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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