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C3MB60

- SYL_RHISN

UniProt

C3MB60 - SYL_RHISN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFRE394:GBYN-3323-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:NGR_c33390
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_1000199220Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi394.NGR_c33390.

    Structurei

    3D structure databases

    ProteinModelPortaliC3MB60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3MB60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATERYNPRD TEPRWQQEWD ARKVFETEND DPREKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAG 100
    WTYQNIAAMK AQLKVMGLSL DWSREFATCD PAYYQRQQYL FLDFLEKGLV 150
    YRRQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS 200
    QDLLDALDGL EQWPEKVRLM QKNWIGRSEG LALRWALDPA TVPGETKELT 250
    VYTTRPDTLF GASFLAISAD HPLAREAAAK DAAIDAFCEE CRRAGTSLAA 300
    LETAEKKGID TGIRARHPFD PEWELPVYVA NFVLMDYGTG AIFGCPSGDQ 350
    RDLDFARKYG LSVVPVVMPK DADAATFTIE DEAYGGDGVM INSRFLDGLS 400
    TEEAFEAVAS KLEQETLDGA PRAERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CEDCGVVPVP KADLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR 500
    RETDTMDTFV DSSWYYARFT APWEDKPTDP KAANHWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMKATGHVA MDEPFKGLFT QGMVVHETYS RGEGAQREWV 600
    TPAEIRIDEI DGRRRAVLIE TGEEVAIGSI EKMSKSKKNV VDPDDIIGSY 650
    GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLV GEAAESLRGA 700
    KASPAKEGEG LAISQAAHRT LRAVEADYDK LAFNKAVARI YELVNVLAAP 750
    LTQVAAGKAD QAVTAAVKDA TTILIDLIAP MMPHLAEECW REIGGEGLIA 800
    ERPWPTFDPA LVVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD 850
    AVKAALNGAS PRKIIVVPQR IVNVVV 876
    Length:876
    Mass (Da):97,961
    Last modified:June 16, 2009 - v1
    Checksum:i247F386ACAF60FEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP27069.1.
    RefSeqiYP_002827822.1. NC_012587.1.

    Genome annotation databases

    EnsemblBacteriaiACP27069; ACP27069; NGR_c33390.
    GeneIDi7792606.
    KEGGirhi:NGR_c33390.
    PATRICi32313209. VBIRhiSp122450_6184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP27069.1 .
    RefSeqi YP_002827822.1. NC_012587.1.

    3D structure databases

    ProteinModelPortali C3MB60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_c33390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP27069 ; ACP27069 ; NGR_c33390 .
    GeneIDi 7792606.
    KEGGi rhi:NGR_c33390.
    PATRICi 32313209. VBIRhiSp122450_6184.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SFRE394:GBYN-3323-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiSYL_RHISN
    AccessioniPrimary (citable) accession number: C3MB60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3