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C3MB60

- SYL_RHISN

UniProt

C3MB60 - SYL_RHISN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRE394:GBYN-3323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NGR_c33390
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Leucine--tRNA ligasePRO_1000199220Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c33390.

Structurei

3D structure databases

ProteinModelPortaliC3MB60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3MB60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATERYNPRD TEPRWQQEWD ARKVFETEND DPREKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAG
110 120 130 140 150
WTYQNIAAMK AQLKVMGLSL DWSREFATCD PAYYQRQQYL FLDFLEKGLV
160 170 180 190 200
YRRQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS
210 220 230 240 250
QDLLDALDGL EQWPEKVRLM QKNWIGRSEG LALRWALDPA TVPGETKELT
260 270 280 290 300
VYTTRPDTLF GASFLAISAD HPLAREAAAK DAAIDAFCEE CRRAGTSLAA
310 320 330 340 350
LETAEKKGID TGIRARHPFD PEWELPVYVA NFVLMDYGTG AIFGCPSGDQ
360 370 380 390 400
RDLDFARKYG LSVVPVVMPK DADAATFTIE DEAYGGDGVM INSRFLDGLS
410 420 430 440 450
TEEAFEAVAS KLEQETLDGA PRAERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CEDCGVVPVP KADLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR
510 520 530 540 550
RETDTMDTFV DSSWYYARFT APWEDKPTDP KAANHWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMKATGHVA MDEPFKGLFT QGMVVHETYS RGEGAQREWV
610 620 630 640 650
TPAEIRIDEI DGRRRAVLIE TGEEVAIGSI EKMSKSKKNV VDPDDIIGSY
660 670 680 690 700
GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLV GEAAESLRGA
710 720 730 740 750
KASPAKEGEG LAISQAAHRT LRAVEADYDK LAFNKAVARI YELVNVLAAP
760 770 780 790 800
LTQVAAGKAD QAVTAAVKDA TTILIDLIAP MMPHLAEECW REIGGEGLIA
810 820 830 840 850
ERPWPTFDPA LVVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD
860 870
AVKAALNGAS PRKIIVVPQR IVNVVV
Length:876
Mass (Da):97,961
Last modified:June 16, 2009 - v1
Checksum:i247F386ACAF60FEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001389 Genomic DNA. Translation: ACP27069.1.
RefSeqiWP_012709816.1. NC_012587.1.
YP_002827822.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP27069; ACP27069; NGR_c33390.
GeneIDi7792606.
KEGGirhi:NGR_c33390.
PATRICi32313209. VBIRhiSp122450_6184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001389 Genomic DNA. Translation: ACP27069.1 .
RefSeqi WP_012709816.1. NC_012587.1.
YP_002827822.1. NC_012587.1.

3D structure databases

ProteinModelPortali C3MB60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_c33390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP27069 ; ACP27069 ; NGR_c33390 .
GeneIDi 7792606.
KEGGi rhi:NGR_c33390.
PATRICi 32313209. VBIRhiSp122450_6184.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SFRE394:GBYN-3323-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiSYL_RHISN
AccessioniPrimary (citable) accession number: C3MB60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3