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C3MAR5 (PUR9_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:NGR_c33280
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000122968

Sequences

Sequence LengthMass (Da)Tools
C3MAR5 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 396CEC3E68E713E0

FASTA53656,436
        10         20         30         40         50         60 
MAVASKKIPA PDEVRIQTAL LSVSDKAGIV ELARALHGKG VRLVSTGGTH KALAAAGLPV 

        70         80         90        100        110        120 
SDVSELTGFP EVMDGRVKTL HPGVHGGLLA IRDDADHKAA MDEHGITGID LAVINLYPFE 

       130        140        150        160        170        180 
EVRAQGGDYP TTVENIDIGG PAMIRASAKN HAYVTIVTDP ADYSALLEEI ADGTTRYAFR 

       190        200        210        220        230        240 
QKMAAKAYAR TAAYDAAISN WFAEALDLAM PRHRVIGGVL KEEMRYGENP HQKAGFYVTG 

       250        260        270        280        290        300 
EQRPGVATAA LLQGKQLSYN NINDTDAAFE LVAEFLPEKA PACAIIKHAN PCGVATAPSL 

       310        320        330        340        350        360 
TEAYRRALAC DSTSAFGGII ALNQELDAET AEEIVKLFTE VIIAPSVSDE AKAIIARKPN 

       370        380        390        400        410        420 
LRLLAAGGLP DARTPGLTAK TVAGGLLVQT RDNGMVEDLE LKVVTKRAPT AQELEDMKFA 

       430        440        450        460        470        480 
FKVAKHVKSN AVVYAKDGQT AGIGAGQMSR VDSARIAAIK AEEAARAHGL AAPLTRGSAV 

       490        500        510        520        530 
ASEAFLPFAD GLLSAIAAGA TAVIQPGGSM RDEEVIAAAN EHNVAMVFTG MRHFRH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP27058.1.
RefSeqYP_002827811.1. NC_012587.1.

3D structure databases

ProteinModelPortalC3MAR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c33280.

Proteomic databases

ProMEXC3MAR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP27058; ACP27058; NGR_c33280.
GeneID7792595.
KEGGrhi:NGR_c33280.
PATRIC32313181. VBIRhiSp122450_6170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycSFRE394:GBYN-3312-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_RHISN
AccessionPrimary (citable) accession number: C3MAR5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways