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C3MAR5

- PUR9_RHISN

UniProt

C3MAR5 - PUR9_RHISN

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciSFRE394:GBYN-3312-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:NGR_c33280
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Bifunctional purine biosynthesis protein PurHPRO_1000122968Add
    BLAST

    Proteomic databases

    ProMEXiC3MAR5.

    Interactioni

    Protein-protein interaction databases

    STRINGi394.NGR_c33280.

    Structurei

    3D structure databases

    ProteinModelPortaliC3MAR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3MAR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVASKKIPA PDEVRIQTAL LSVSDKAGIV ELARALHGKG VRLVSTGGTH    50
    KALAAAGLPV SDVSELTGFP EVMDGRVKTL HPGVHGGLLA IRDDADHKAA 100
    MDEHGITGID LAVINLYPFE EVRAQGGDYP TTVENIDIGG PAMIRASAKN 150
    HAYVTIVTDP ADYSALLEEI ADGTTRYAFR QKMAAKAYAR TAAYDAAISN 200
    WFAEALDLAM PRHRVIGGVL KEEMRYGENP HQKAGFYVTG EQRPGVATAA 250
    LLQGKQLSYN NINDTDAAFE LVAEFLPEKA PACAIIKHAN PCGVATAPSL 300
    TEAYRRALAC DSTSAFGGII ALNQELDAET AEEIVKLFTE VIIAPSVSDE 350
    AKAIIARKPN LRLLAAGGLP DARTPGLTAK TVAGGLLVQT RDNGMVEDLE 400
    LKVVTKRAPT AQELEDMKFA FKVAKHVKSN AVVYAKDGQT AGIGAGQMSR 450
    VDSARIAAIK AEEAARAHGL AAPLTRGSAV ASEAFLPFAD GLLSAIAAGA 500
    TAVIQPGGSM RDEEVIAAAN EHNVAMVFTG MRHFRH 536
    Length:536
    Mass (Da):56,436
    Last modified:June 16, 2009 - v1
    Checksum:i396CEC3E68E713E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP27058.1.
    RefSeqiYP_002827811.1. NC_012587.1.

    Genome annotation databases

    EnsemblBacteriaiACP27058; ACP27058; NGR_c33280.
    GeneIDi7792595.
    KEGGirhi:NGR_c33280.
    PATRICi32313181. VBIRhiSp122450_6170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001389 Genomic DNA. Translation: ACP27058.1 .
    RefSeqi YP_002827811.1. NC_012587.1.

    3D structure databases

    ProteinModelPortali C3MAR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_c33280.

    Proteomic databases

    ProMEXi C3MAR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP27058 ; ACP27058 ; NGR_c33280 .
    GeneIDi 7792595.
    KEGGi rhi:NGR_c33280.
    PATRICi 32313181. VBIRhiSp122450_6170.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci SFRE394:GBYN-3312-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiPUR9_RHISN
    AccessioniPrimary (citable) accession number: C3MAR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3