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C3MAR5

- PUR9_RHISN

UniProt

C3MAR5 - PUR9_RHISN

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, NGR_c33280
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSFRE394:GBYN-3312-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:NGR_c33280
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122968Add
BLAST

Proteomic databases

ProMEXiC3MAR5.

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_c33280.

Structurei

3D structure databases

ProteinModelPortaliC3MAR5.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C3MAR5-1 [UniParc]FASTAAdd to Basket

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MAVASKKIPA PDEVRIQTAL LSVSDKAGIV ELARALHGKG VRLVSTGGTH    50
KALAAAGLPV SDVSELTGFP EVMDGRVKTL HPGVHGGLLA IRDDADHKAA 100
MDEHGITGID LAVINLYPFE EVRAQGGDYP TTVENIDIGG PAMIRASAKN 150
HAYVTIVTDP ADYSALLEEI ADGTTRYAFR QKMAAKAYAR TAAYDAAISN 200
WFAEALDLAM PRHRVIGGVL KEEMRYGENP HQKAGFYVTG EQRPGVATAA 250
LLQGKQLSYN NINDTDAAFE LVAEFLPEKA PACAIIKHAN PCGVATAPSL 300
TEAYRRALAC DSTSAFGGII ALNQELDAET AEEIVKLFTE VIIAPSVSDE 350
AKAIIARKPN LRLLAAGGLP DARTPGLTAK TVAGGLLVQT RDNGMVEDLE 400
LKVVTKRAPT AQELEDMKFA FKVAKHVKSN AVVYAKDGQT AGIGAGQMSR 450
VDSARIAAIK AEEAARAHGL AAPLTRGSAV ASEAFLPFAD GLLSAIAAGA 500
TAVIQPGGSM RDEEVIAAAN EHNVAMVFTG MRHFRH 536
Length:536
Mass (Da):56,436
Last modified:June 16, 2009 - v1
Checksum:i396CEC3E68E713E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27058.1.
RefSeqiYP_002827811.1. NC_012587.1.

Genome annotation databases

EnsemblBacteriaiACP27058; ACP27058; NGR_c33280.
GeneIDi7792595.
KEGGirhi:NGR_c33280.
PATRICi32313181. VBIRhiSp122450_6170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001389 Genomic DNA. Translation: ACP27058.1 .
RefSeqi YP_002827811.1. NC_012587.1.

3D structure databases

ProteinModelPortali C3MAR5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 394.NGR_c33280.

Proteomic databases

ProMEXi C3MAR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP27058 ; ACP27058 ; NGR_c33280 .
GeneIDi 7792595.
KEGGi rhi:NGR_c33280.
PATRICi 32313181. VBIRhiSp122450_6170.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SFRE394:GBYN-3312-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiPUR9_RHISN
AccessioniPrimary (citable) accession number: C3MAR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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