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C3M930 (HGD_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:NGR_c29980
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_1000190375

Sites

Metal binding3471Iron By similarity
Metal binding3531Iron By similarity
Metal binding3831Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
C3M930 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 036CCDAB72DCBD48

FASTA45350,598
        10         20         30         40         50         60 
MLGKAEKRSE ALAAEALAYM PGFGNDFETE SLPGALPQGQ NSPQKCNYGL YAEQLSGSPF 

        70         80         90        100        110        120 
TAPRGTNERS WLYRIRPSVR HTGRFAKIDY PHWKTAPHIA EHALALGQLR WNPLPEPTGE 

       130        140        150        160        170        180 
LNFLQGIRTM TTAGDVLTQV GMAAHAYVFN ADMVDDYFFN ADGELLIVPE MGALQVFTEL 

       190        200        210        220        230        240 
GKMDVAPSEI CLVPRGTMFK VARLGEEKAW RGYICENYGA KFTLPDRGPI GANCLANPRD 

       250        260        270        280        290        300 
FKTPVAAFED KETPCRVQVK WCGSFHTVEI GHSPLDVVAW HGNYAPYKYD LKTFSPVGAI 

       310        320        330        340        350        360 
LFDHPDPSIF TVLTAPSGEE GTANVDFVLF PPRWLVAEHT FRPPWYHRNI MSEFMGLIHG 

       370        380        390        400        410        420 
RYDAKEEGFV PGGMSLHNMM LAHGPDTSGF EKATNGELKP VKLDNTMAFM FETRFPQQLT 

       430        440        450 
RFAAELETLQ DDYIDCWAGL RKRFNGTPEG DWS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001389 Genomic DNA. Translation: ACP26741.1.
RefSeqYP_002827494.1. NC_012587.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_c29980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP26741; ACP26741; NGR_c29980.
GeneID7792270.
KEGGrhi:NGR_c29980.
PATRIC32312499. VBIRhiSp122450_5838.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycSFRE394:GBYN-2987-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_RHISN
AccessionPrimary (citable) accession number: C3M930
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways