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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Gene

glpB

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.UniRule annotation

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotation

Pathway:iglycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-3474-MONOMER.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit BUniRule annotation (EC:1.1.5.3UniRule annotation)
Short name:
Anaerobic G-3-P dehydrogenase subunit BUniRule annotation
Short name:
Anaerobic G3Pdhase BUniRule annotation
Gene namesi
Name:glpBUniRule annotation
Ordered Locus Names:VCM66_A0707
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Anaerobic glycerol-3-phosphate dehydrogenase subunit BPRO_1000148361Add
BLAST

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3LW14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anaerobic G-3-P dehydrogenase subunit B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3075.
HOGENOMiHOG000278489.
KOiK00112.
OMAiDVFEVPM.
OrthoDBiEOG6K6V62.

Family and domain databases

HAMAPiMF_00753. Glycerol3P_GlpB.
InterProiIPR003953. FAD_bind_dom.
IPR009158. G3P_DH_GlpB_su.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000141. Anaerobic_G3P_dh. 1 hit.
TIGRFAMsiTIGR03378. glycerol3P_GlpB. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LW14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHYDVAVIG GGIAGYSAAL RALQAGKKVV LINQGQSALH FSSGSIDVLG
60 70 80 90 100
RLPDGSVVNQ PFDALSALQQ QVPEHPYSKV GRKNSEKGLM WFKRTLDSAH
110 120 130 140 150
VPLHHEPDGA NHWRITPLGT LKNTWLSQPF VYPYRGNADF SRIMIVAIDG
160 170 180 190 200
YRDFQPAMLR DNLAQRPELA NTPMLTVNVS IPGFEGFRRN PNELRSIDIA
210 220 230 240 250
RLLRQESAWN ALCDQLMRVA RPDDLVIMPA IMGNGDGLHL MSKLQQVTQL
260 270 280 290 300
RFHEVPTMPP SLLGIRIEEA LHRSFIQGGG VQLKGDKVID GDFAGSRLTA
310 320 330 340 350
IHTQNLRDFP ISAEHYVMAT GSYFSQGLQA SQHAIQEPTF ALDVQQNPDR
360 370 380 390 400
AQWRHAQFIA AQSHPFMTFG VTTDANLHPS RQGKTIDNLW CCGAMLSGYD
410 420 430
PVFEGCGGGV AIATAYHAVE QILATYAQTK QPEVLL
Length:436
Mass (Da):48,094
Last modified:June 16, 2009 - v1
Checksum:i9AB04D632D15CDD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001234 Genomic DNA. Translation: ACP07669.1.
RefSeqiWP_000972325.1. NC_012580.1.

Genome annotation databases

EnsemblBacteriaiACP07669; ACP07669; VCM66_A0707.
KEGGivcm:VCM66_A0707.
PATRICi20070467. VBIVibCho108967_3242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001234 Genomic DNA. Translation: ACP07669.1.
RefSeqiWP_000972325.1. NC_012580.1.

3D structure databases

ProteinModelPortaliC3LW14.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP07669; ACP07669; VCM66_A0707.
KEGGivcm:VCM66_A0707.
PATRICi20070467. VBIVibCho108967_3242.

Phylogenomic databases

eggNOGiCOG3075.
HOGENOMiHOG000278489.
KOiK00112.
OMAiDVFEVPM.
OrthoDBiEOG6K6V62.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.
BioCyciVCHO579112:GJAW-3474-MONOMER.

Family and domain databases

HAMAPiMF_00753. Glycerol3P_GlpB.
InterProiIPR003953. FAD_bind_dom.
IPR009158. G3P_DH_GlpB_su.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000141. Anaerobic_G3P_dh. 1 hit.
TIGRFAMsiTIGR03378. glycerol3P_GlpB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiGLPB_VIBCM
AccessioniPrimary (citable) accession number: C3LW14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.