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C3LUU7

- GCSP_VIBCM

UniProt

C3LUU7 - GCSP_VIBCM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, VCM66_A0275
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-3050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VCM66_A0275
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000147972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi579112.VCM66_A0275.

Structurei

3D structure databases

ProteinModelPortaliC3LUU7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LUU7-1 [UniParc]FASTAAdd to Basket

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MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI    50
RLEAPMQLAP AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR 100
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTAM EIANASLLDE 150
ATAAAEAMAL CQRAGKSKSN LFFVADDVHP QTIEVVKTRA AFLGFEVKVD 200
SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL VTVATDLLAS 250
VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI 300
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH 350
GPQGLRTIAR RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL 400
YQAAQQANIN LRKLPNQLGV SFDETTTVAD VEALFAIFGI KEEVHALSDR 450
IATNELAAIP ESCRRQSAFL THPVFNTHHS ETQMLRYMKH LENKDFSLTH 500
GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG YAALAEDLKQ 550
KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA 600
HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP 650
STHGVYEQQV REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIEGGVEG SDFAVSAADL 750
GSASILPISW AYIAMMGADG LAEATKLAIL NANYVMERLR PHYPILYRGA 800
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL 900
REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID 950
SYQD 954
Length:954
Mass (Da):103,954
Last modified:June 16, 2009 - v1
Checksum:iB2336F8CE80C806A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1.
RefSeqiYP_002811909.1. NC_012580.1.

Genome annotation databases

EnsemblBacteriaiACP07252; ACP07252; VCM66_A0275.
GeneIDi7781564.
KEGGivcm:VCM66_A0275.
PATRICi20069630. VBIVibCho108967_2825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1 .
RefSeqi YP_002811909.1. NC_012580.1.

3D structure databases

ProteinModelPortali C3LUU7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_A0275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP07252 ; ACP07252 ; VCM66_A0275 .
GeneIDi 7781564.
KEGGi vcm:VCM66_A0275.
PATRICi 20069630. VBIVibCho108967_2825.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VCHO579112:GJAW-3050-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiGCSP_VIBCM
AccessioniPrimary (citable) accession number: C3LUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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