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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-3050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VCM66_A0275
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3LUU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHTQVDLM.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LUU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI
60 70 80 90 100
RLEAPMQLAP AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTAM EIANASLLDE
160 170 180 190 200
ATAAAEAMAL CQRAGKSKSN LFFVADDVHP QTIEVVKTRA AFLGFEVKVD
210 220 230 240 250
SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL VTVATDLLAS
260 270 280 290 300
VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI
310 320 330 340 350
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH
360 370 380 390 400
GPQGLRTIAR RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL
410 420 430 440 450
YQAAQQANIN LRKLPNQLGV SFDETTTVAD VEALFAIFGI KEEVHALSDR
460 470 480 490 500
IATNELAAIP ESCRRQSAFL THPVFNTHHS ETQMLRYMKH LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG YAALAEDLKQ
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP
660 670 680 690 700
STHGVYEQQV REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIEGGVEG SDFAVSAADL
760 770 780 790 800
GSASILPISW AYIAMMGADG LAEATKLAIL NANYVMERLR PHYPILYRGA
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL
910 920 930 940 950
REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID

SYQD
Length:954
Mass (Da):103,954
Last modified:June 16, 2009 - v1
Checksum:iB2336F8CE80C806A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1.
RefSeqiWP_000137693.1. NC_012580.1.
YP_002811909.1. NC_012580.1.

Genome annotation databases

EnsemblBacteriaiACP07252; ACP07252; VCM66_A0275.
KEGGivcm:VCM66_A0275.
PATRICi20069630. VBIVibCho108967_2825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1.
RefSeqiWP_000137693.1. NC_012580.1.
YP_002811909.1. NC_012580.1.

3D structure databases

ProteinModelPortaliC3LUU7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP07252; ACP07252; VCM66_A0275.
KEGGivcm:VCM66_A0275.
PATRICi20069630. VBIVibCho108967_2825.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHTQVDLM.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-3050-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiGCSP_VIBCM
AccessioniPrimary (citable) accession number: C3LUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.