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C3LUU7 (GCSP_VIBCM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:VCM66_A0275
OrganismVibrio cholerae serotype O1 (strain M66-2) [Complete proteome] [HAMAP]
Taxonomic identifier579112 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000147972

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C3LUU7 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: B2336F8CE80C806A

FASTA954103,954
        10         20         30         40         50         60 
MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI RLEAPMQLAP 

        70         80         90        100        110        120 
AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR NVMENPGWYT AYTPYQPEIS 

       130        140        150        160        170        180 
QGRLESLLNY QQMVMDLTAM EIANASLLDE ATAAAEAMAL CQRAGKSKSN LFFVADDVHP 

       190        200        210        220        230        240 
QTIEVVKTRA AFLGFEVKVD SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL 

       250        260        270        280        290        300 
VTVATDLLAS VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI 

       310        320        330        340        350        360 
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH GPQGLRTIAR 

       370        380        390        400        410        420 
RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL YQAAQQANIN LRKLPNQLGV 

       430        440        450        460        470        480 
SFDETTTVAD VEALFAIFGI KEEVHALSDR IATNELAAIP ESCRRQSAFL THPVFNTHHS 

       490        500        510        520        530        540 
ETQMLRYMKH LENKDFSLTH GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG 

       550        560        570        580        590        600 
YAALAEDLKQ KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA 

       610        620        630        640        650        660 
HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP STHGVYEQQV 

       670        680        690        700        710        720 
REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKSHLAPFL PGHIEGGVEG SDFAVSAADL GSASILPISW AYIAMMGADG LAEATKLAIL 

       790        800        810        820        830        840 
NANYVMERLR PHYPILYRGA NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM 

       850        860        870        880        890        900 
SFPVAGTLMV EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL 

       910        920        930        940        950 
REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID SYQD 

« Hide

References

[1]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M66-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001234 Genomic DNA. Translation: ACP07252.1.
RefSeqYP_002811909.1. NC_012580.1.

3D structure databases

ProteinModelPortalC3LUU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING579112.VCM66_A0275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP07252; ACP07252; VCM66_A0275.
GeneID7781564.
KEGGvcm:VCM66_A0275.
PATRIC20069630. VBIVibCho108967_2825.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHTQVDLM.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycVCHO579112:GJAW-3050-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_VIBCM
AccessionPrimary (citable) accession number: C3LUU7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families