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C3LUU7

- GCSP_VIBCM

UniProt

C3LUU7 - GCSP_VIBCM

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-3050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VCM66_A0275
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi579112.VCM66_A0275.

Structurei

3D structure databases

ProteinModelPortaliC3LUU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LUU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI
60 70 80 90 100
RLEAPMQLAP AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTAM EIANASLLDE
160 170 180 190 200
ATAAAEAMAL CQRAGKSKSN LFFVADDVHP QTIEVVKTRA AFLGFEVKVD
210 220 230 240 250
SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL VTVATDLLAS
260 270 280 290 300
VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI
310 320 330 340 350
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH
360 370 380 390 400
GPQGLRTIAR RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL
410 420 430 440 450
YQAAQQANIN LRKLPNQLGV SFDETTTVAD VEALFAIFGI KEEVHALSDR
460 470 480 490 500
IATNELAAIP ESCRRQSAFL THPVFNTHHS ETQMLRYMKH LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG YAALAEDLKQ
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP
660 670 680 690 700
STHGVYEQQV REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIEGGVEG SDFAVSAADL
760 770 780 790 800
GSASILPISW AYIAMMGADG LAEATKLAIL NANYVMERLR PHYPILYRGA
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL
910 920 930 940 950
REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID

SYQD
Length:954
Mass (Da):103,954
Last modified:June 16, 2009 - v1
Checksum:iB2336F8CE80C806A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1.
RefSeqiYP_002811909.1. NC_012580.1.

Genome annotation databases

EnsemblBacteriaiACP07252; ACP07252; VCM66_A0275.
GeneIDi7781564.
KEGGivcm:VCM66_A0275.
PATRICi20069630. VBIVibCho108967_2825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001234 Genomic DNA. Translation: ACP07252.1 .
RefSeqi YP_002811909.1. NC_012580.1.

3D structure databases

ProteinModelPortali C3LUU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_A0275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP07252 ; ACP07252 ; VCM66_A0275 .
GeneIDi 7781564.
KEGGi vcm:VCM66_A0275.
PATRICi 20069630. VBIVibCho108967_2825.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VCHO579112:GJAW-3050-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiGCSP_VIBCM
AccessioniPrimary (citable) accession number: C3LUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3