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C3LUU7

- GCSP_VIBCM

UniProt

C3LUU7 - GCSP_VIBCM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-3050-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:VCM66_A0275
    OrganismiVibrio cholerae serotype O1 (strain M66-2)
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147972Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi579112.VCM66_A0275.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LUU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3LUU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI    50
    RLEAPMQLAP AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR 100
    NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTAM EIANASLLDE 150
    ATAAAEAMAL CQRAGKSKSN LFFVADDVHP QTIEVVKTRA AFLGFEVKVD 200
    SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL VTVATDLLAS 250
    VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI 300
    GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH 350
    GPQGLRTIAR RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL 400
    YQAAQQANIN LRKLPNQLGV SFDETTTVAD VEALFAIFGI KEEVHALSDR 450
    IATNELAAIP ESCRRQSAFL THPVFNTHHS ETQMLRYMKH LENKDFSLTH 500
    GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG YAALAEDLKQ 550
    KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA 600
    HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP 650
    STHGVYEQQV REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIEGGVEG SDFAVSAADL 750
    GSASILPISW AYIAMMGADG LAEATKLAIL NANYVMERLR PHYPILYRGA 800
    NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
    EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL 900
    REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID 950
    SYQD 954
    Length:954
    Mass (Da):103,954
    Last modified:June 16, 2009 - v1
    Checksum:iB2336F8CE80C806A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001234 Genomic DNA. Translation: ACP07252.1.
    RefSeqiYP_002811909.1. NC_012580.1.

    Genome annotation databases

    EnsemblBacteriaiACP07252; ACP07252; VCM66_A0275.
    GeneIDi7781564.
    KEGGivcm:VCM66_A0275.
    PATRICi20069630. VBIVibCho108967_2825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001234 Genomic DNA. Translation: ACP07252.1 .
    RefSeqi YP_002811909.1. NC_012580.1.

    3D structure databases

    ProteinModelPortali C3LUU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_A0275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP07252 ; ACP07252 ; VCM66_A0275 .
    GeneIDi 7781564.
    KEGGi vcm:VCM66_A0275.
    PATRICi 20069630. VBIVibCho108967_2825.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci VCHO579112:GJAW-3050-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2.

    Entry informationi

    Entry nameiGCSP_VIBCM
    AccessioniPrimary (citable) accession number: C3LUU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3