ID   C3LU56_VIBCM            Unreviewed;       848 AA.
AC   C3LU56;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Chitinase {ECO:0000313|EMBL:ACP07011.1};
DE            EC=3.2.1.14 {ECO:0000313|EMBL:ACP07011.1};
GN   Name=chiA-2 {ECO:0000313|EMBL:ACP07011.1};
GN   OrderedLocusNames=VCM66_A0026 {ECO:0000313|EMBL:ACP07011.1};
OS   Vibrio cholerae serotype O1 (strain M66-2).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=579112 {ECO:0000313|EMBL:ACP07011.1};
RN   [1] {ECO:0000313|EMBL:ACP07011.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M66-2 {ECO:0000313|EMBL:ACP07011.1};
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC       class II subfamily. {ECO:0000256|ARBA:ARBA00009121}.
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DR   EMBL; CP001234; ACP07011.1; -; Genomic_DNA.
DR   RefSeq; WP_001894571.1; NC_012580.1.
DR   AlphaFoldDB; C3LU56; -.
DR   SMR; C3LU56; -.
DR   CAZy; CBM5; Carbohydrate-Binding Module Family 5.
DR   CAZy; GH18; Glycoside Hydrolase Family 18.
DR   GeneID; 69721837; -.
DR   KEGG; vcm:VCM66_A0026; -.
DR   HOGENOM; CLU_002833_14_0_6; -.
DR   Proteomes; UP000001217; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006032; P:chitin catabolic process; IEA:InterPro.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd12215; ChiC_BD; 1.
DR   CDD; cd02848; E_set_Chitinase_N; 1.
DR   CDD; cd06548; GH18_chitinase; 1.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 3.10.50.10; -; 1.
DR   Gene3D; 2.10.10.20; Carbohydrate-binding module superfamily 5/12; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR003610; CBM_fam5/12.
DR   InterPro; IPR036573; CBM_sf_5/12.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR013540; ChitinaseA_N.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR11177; CHITINASE; 1.
DR   PANTHER; PTHR11177:SF317; CHITINASE 11; 1.
DR   Pfam; PF02839; CBM_5_12; 1.
DR   Pfam; PF08329; ChitinaseA_N; 1.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   Pfam; PF18911; PKD_4; 2.
DR   SMART; SM00495; ChtBD3; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SMART; SM00089; PKD; 3.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51055; Carbohydrate binding domain; 1.
DR   SUPFAM; SSF54556; Chitinase insertion domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS01095; GH18_1; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023326};
KW   Chitin degradation {ECO:0000256|ARBA:ARBA00023024};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000489};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000489};
KW   Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..848
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002929284"
FT   DOMAIN          159..590
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
SQ   SEQUENCE   848 AA;  90114 MW;  66BECA294FA58233 CRC64;
     MNRMTLCAAS IACALASTAM AAPSAPSVDV YGSNNLQFSK IELAMETTAG YNQMVKYHEE
     APITLKFNQW SGVTGNTYKI YFDGVEVATG PISGSQTTAQ FTYPKGGVYQ LVIEACDATG
     CTKSAPSEIT IADTDGSHLK PLKMNVDPNN KSYTIPQNTV VGTYFVEWSI YDRKFTVDNI
     PGQNLTHILY GFIPICGPNE SLKSVGGNSF NALQTACKGV PDFEVVIHDP WAAYQKSFPQ
     AGHQYSSPIK GNYAMLMALK KTYPDLKIIP SIGGWTLSDP FFSFTDKAKR DVFVASVKRF
     LKTWKFYDGV DIDWEYPGGG GQAADLGDPV KDGPAYVALM AELRAMLDEL EAETGRKYEL
     TSAIGVGHDK IEDVNYGQAV QYMDYIFAMT YDFYGGWNNV LGHQTALYCG SFMRPGQCDG
     KGVDENGEPY KGPAYTTDNG IQLLLAQGVP PSKLVVGAAM YGRGWEGVTP ASLKDPNDPM
     TGVGNGKLKG TTAQGVWEAG VIDYKGVKNF MLGANKTGVN GFEYGYDEQA EAPWVWNRTT
     GQLVTFDDDR SVKAKGAYVR NLGLAGLFSW EIDADNGDIL NAMHEGLAGG TTTPPVNKAP
     VANAGADITV TGPAAVSLDG SASKDSDGSI ASYLWEQTAG PAVTLTGANS AKASFNAAEV
     TEKQTFTFKL TVTDNKGATA TDTVVVTVNP KSTTPVNTAP VAAVSAPASV KAGATVVVDA
     SASSDADQDP LSFTWDLPVG INATVQGAKV TFVAGEYSQD TSLSFTVTVS DGKATSTASA
     SVLVEKKVGG GDACTNLWNA DAIYTGGQQV TWAGKTWEAK WWTRGEDPSK SGQWGVWKDL
     GAASCSTH
//