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C3LTF1

- C3LTF1_VIBCM

UniProt

C3LTF1 - C3LTF1_VIBCM

Protein

NADPH-dependent 7-cyano-7-deazaguanine reductase

Gene

queF

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).UniRule annotationSAAS annotation

    Catalytic activityi

    7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei194 – 1941Thioimide intermediateUniRule annotation
    Active sitei201 – 2011Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi95 – 962NADPHUniRule annotation
    Nucleotide bindingi262 – 2632NADPHUniRule annotation

    GO - Molecular functioni

    1. oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Source: InterPro
    2. preQ1 synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Queuosine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-916-MONOMER.
    UniPathwayiUPA00392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH-dependent 7-cyano-7-deazaguanine reductaseUniRule annotation (EC:1.7.1.13UniRule annotation)
    Alternative name(s):
    7-cyano-7-carbaguanine reductaseUniRule annotation
    NADPH-dependent nitrile oxidoreductaseUniRule annotation
    PreQ(0) reductaseUniRule annotation
    Gene namesi
    Name:queFUniRule annotation
    Ordered Locus Names:VCM66_0859Imported
    OrganismiVibrio cholerae serotype O1 (strain M66-2)Imported
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi579112.VCM66_0859.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LTF1.
    SMRiC3LTF1. Positions 27-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 953Substrate bindingUniRule annotation
    Regioni233 – 2342Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0780.
    HOGENOMiHOG000273755.
    KOiK06879.
    OMAiIFCDLMH.
    OrthoDBiEOG6D5G0M.

    Family and domain databases

    HAMAPiMF_00817. QueF_type2.
    InterProiIPR029500. QueF.
    IPR029139. QueF_N.
    IPR016428. QueF_type2.
    [Graphical view]
    PfamiPF14489. QueF. 1 hit.
    PF14819. QueF_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
    TIGRFAMsiTIGR03138. QueF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3LTF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRLKNMSKY SDAKELASLT LGKKTEYANQ YDPSLLQPVP RSLNRNDLHL    50
    SATLPFQGCD IWTLYELSWL NQKGLPQVAI GEVSIPATSA NLIESKSFKL 100
    YLNSYNQTRF ASWDEVQTRL VHDLSACAGE TVTVNVKSLN EYTAEPIVTM 150
    QGECIDDQDI EIANYEFDDA LLQGAAQGEE VSEVLHSHLL KSNCLITNQP 200
    DWGSVEIAYH GAKMNREALL RYLVSFREHN EFHEQCVERI FTDIMRYCQP 250
    QSLTVYARYT RRGGLDINPF RSSHQSAPNH NQRMARQ 287
    Length:287
    Mass (Da):32,726
    Last modified:June 16, 2009 - v1
    Checksum:iC7A848947FAF6A08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP05177.1.
    RefSeqiWP_001880724.1. NC_012578.1.
    YP_002809628.1. NC_012578.1.

    Genome annotation databases

    EnsemblBacteriaiACP05177; ACP05177; VCM66_0859.
    GeneIDi7772138.
    KEGGivcm:VCM66_0859.
    PATRICi20065515. VBIVibCho108967_0817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP05177.1 .
    RefSeqi WP_001880724.1. NC_012578.1.
    YP_002809628.1. NC_012578.1.

    3D structure databases

    ProteinModelPortali C3LTF1.
    SMRi C3LTF1. Positions 27-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_0859.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP05177 ; ACP05177 ; VCM66_0859 .
    GeneIDi 7772138.
    KEGGi vcm:VCM66_0859.
    PATRICi 20065515. VBIVibCho108967_0817.

    Phylogenomic databases

    eggNOGi COG0780.
    HOGENOMi HOG000273755.
    KOi K06879.
    OMAi IFCDLMH.
    OrthoDBi EOG6D5G0M.

    Enzyme and pathway databases

    UniPathwayi UPA00392 .
    BioCyci VCHO579112:GJAW-916-MONOMER.

    Family and domain databases

    HAMAPi MF_00817. QueF_type2.
    InterProi IPR029500. QueF.
    IPR029139. QueF_N.
    IPR016428. QueF_type2.
    [Graphical view ]
    Pfami PF14489. QueF. 1 hit.
    PF14819. QueF_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
    TIGRFAMsi TIGR03138. QueF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2Imported.

    Entry informationi

    Entry nameiC3LTF1_VIBCM
    AccessioniPrimary (citable) accession number: C3LTF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3