SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C3LTF1

- C3LTF1_VIBCM

UniProt

C3LTF1 - C3LTF1_VIBCM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NADPH-dependent 7-cyano-7-deazaguanine reductase

Gene
queF, VCM66_0859
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei194 – 1941Thioimide intermediate By similarityUniRule annotation
Active sitei201 – 2011Proton donor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 962NADPH By similarityUniRule annotation
Nucleotide bindingi262 – 2632NADPH By similarityUniRule annotation

GO - Molecular functioni

  1. oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Source: InterPro
  2. preQ1 synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotations

Keywords - Biological processi

Queuosine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-916-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductaseUniRule annotation (EC:1.7.1.13UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine reductase
NADPH-dependent nitrile oxidoreductase
PreQ(0) reductase
Gene namesi
Name:queFUniRule annotation
Ordered Locus Names:VCM66_0859Imported
OrganismiVibrio cholerae serotype O1 (strain M66-2)Imported
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi579112.VCM66_0859.

Structurei

3D structure databases

ProteinModelPortaliC3LTF1.
SMRiC3LTF1. Positions 27-287.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 953Substrate binding By similarityUniRule annotation
Regioni233 – 2342Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0780.
HOGENOMiHOG000273755.
KOiK06879.
OMAiIFCDLMH.
OrthoDBiEOG6D5G0M.

Family and domain databases

HAMAPiMF_00817. QueF_type2.
InterProiIPR029500. QueF.
IPR029139. QueF_N.
IPR016428. QueF_type2.
[Graphical view]
PfamiPF14489. QueF. 1 hit.
PF14819. QueF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsiTIGR03138. QueF. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LTF1-1 [UniParc]FASTAAdd to Basket

« Hide

MNRLKNMSKY SDAKELASLT LGKKTEYANQ YDPSLLQPVP RSLNRNDLHL    50
SATLPFQGCD IWTLYELSWL NQKGLPQVAI GEVSIPATSA NLIESKSFKL 100
YLNSYNQTRF ASWDEVQTRL VHDLSACAGE TVTVNVKSLN EYTAEPIVTM 150
QGECIDDQDI EIANYEFDDA LLQGAAQGEE VSEVLHSHLL KSNCLITNQP 200
DWGSVEIAYH GAKMNREALL RYLVSFREHN EFHEQCVERI FTDIMRYCQP 250
QSLTVYARYT RRGGLDINPF RSSHQSAPNH NQRMARQ 287
Length:287
Mass (Da):32,726
Last modified:June 16, 2009 - v1
Checksum:iC7A848947FAF6A08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05177.1.
RefSeqiWP_001880724.1. NC_012578.1.
YP_002809628.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP05177; ACP05177; VCM66_0859.
GeneIDi7772138.
KEGGivcm:VCM66_0859.
PATRICi20065515. VBIVibCho108967_0817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05177.1 .
RefSeqi WP_001880724.1. NC_012578.1.
YP_002809628.1. NC_012578.1.

3D structure databases

ProteinModelPortali C3LTF1.
SMRi C3LTF1. Positions 27-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_0859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP05177 ; ACP05177 ; VCM66_0859 .
GeneIDi 7772138.
KEGGi vcm:VCM66_0859.
PATRICi 20065515. VBIVibCho108967_0817.

Phylogenomic databases

eggNOGi COG0780.
HOGENOMi HOG000273755.
KOi K06879.
OMAi IFCDLMH.
OrthoDBi EOG6D5G0M.

Enzyme and pathway databases

UniPathwayi UPA00392 .
BioCyci VCHO579112:GJAW-916-MONOMER.

Family and domain databases

HAMAPi MF_00817. QueF_type2.
InterProi IPR029500. QueF.
IPR029139. QueF_N.
IPR016428. QueF_type2.
[Graphical view ]
Pfami PF14489. QueF. 1 hit.
PF14819. QueF_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsi TIGR03138. QueF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2Imported.

Entry informationi

Entry nameiC3LTF1_VIBCM
AccessioniPrimary (citable) accession number: C3LTF1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi