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C3LRX0

- TRMB_VIBCM

UniProt

C3LRX0 - TRMB_VIBCM

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, VCM66_0438
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei93 – 931S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Active sitei143 – 1431 By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei180 – 1801Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-482-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:VCM66_0438
    OrganismiVibrio cholerae serotype O1 (strain M66-2)
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_1000149671Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi579112.VCM66_0438.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LRX0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni217 – 2204Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3LRX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEVITQEYT EDGKVLRRIR SFVRREGRLT KGQEAAMKEC WPTMGIDYQP    50
    ELLDWQQVFG NDNPVVLEIG FGMGASLVEM AKNAPEKNFL GIEVHSPGVG 100
    ACLASAREAG VTNLRVMCHD AVEVFAHMIP DNSLHTLQLF FPDPWHKKRH 150
    HKRRIVQLEF AEMVRQKLMI GSGVFHMATD WENYAEHMVE VMNQAPGFAN 200
    LATDGDYVPR PDERPLTKFE QRGHRLGHGV WDIKYQRTA 239
    Length:239
    Mass (Da):27,315
    Last modified:June 16, 2009 - v1
    Checksum:i6FDBB2CFC08ECC92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP04763.1.
    RefSeqiYP_002809214.1. NC_012578.1.

    Genome annotation databases

    EnsemblBacteriaiACP04763; ACP04763; VCM66_0438.
    GeneIDi7771724.
    KEGGivcm:VCM66_0438.
    PATRICi20064682. VBIVibCho108967_0417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP04763.1 .
    RefSeqi YP_002809214.1. NC_012578.1.

    3D structure databases

    ProteinModelPortali C3LRX0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_0438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP04763 ; ACP04763 ; VCM66_0438 .
    GeneIDi 7771724.
    KEGGi vcm:VCM66_0438.
    PATRICi 20064682. VBIVibCho108967_0417.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci VCHO579112:GJAW-482-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2.

    Entry informationi

    Entry nameiTRMB_VIBCM
    AccessioniPrimary (citable) accession number: C3LRX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: June 11, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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