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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491UniRule annotation
Active sitei554 – 5541UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-2651-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:VCM66_2566Imported
OrganismiVibrio cholerae serotype O1 (strain M66-2)Imported
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217 Componenti: Chromosome I

PTM / Processingi

Proteomic databases

PRIDEiC3LRV7.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi579112.VCM66_2566.

Structurei

3D structure databases

ProteinModelPortaliC3LRV7.
SMRiC3LRV7. Positions 15-887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LRV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVIFFQGRM TMNEKYAALK SNVSMLGRLL GQTIQAADGD VILAKVETIR
60 70 80 90 100
KLSKSARAGN QADRELLIEE IKNLPNHQLT PVARAFNQFL NLTNIAEQYH
110 120 130 140 150
TISRHCESHV NELDAIGSLF AKLAQKSVSK FDTAQAIRDL NIELVLTAHP
160 170 180 190 200
TEITRRTMIN KLVKINECLS KLELSDLSPK ERHKTERRLE QLIAQSWHSD
210 220 230 240 250
VIRQQRPTPL DEAKWGFAVV ENSLWHAVPE FLRELDEQVK SYLGEGLPID
260 270 280 290 300
ARPVHFSSWM GGDRDGNPFV THTITREVLL LSRWKAADLY LTDINELVSE
310 320 330 340 350
LSMTKCNEAV RALAGEEHEP YRAILKPIRS LLQETIEILD AKLNGQKLAV
360 370 380 390 400
KAPLQTADQL WEPLYACYQS LHECGMGVIA DGSLLDTLRR IKAFGVHLVR
410 420 430 440 450
LDVRQESSRH AEVISELTRH LGIGDYNQWS EQDKIAFLTT ELNSKRPLLP
460 470 480 490 500
RDWQPSPQVK EVLDTCKIIA AQSKDAFGAY VISMARTASD VLAVHLLLQE
510 520 530 540 550
AGCPYRMDVC PLFETLDDLN NAESVIRQLM NIDLYRGFIQ NHQMVMIGYS
560 570 580 590 600
DSAKDAGVMA AGWAQYRAME ALVKVGEEAG IELTLFHGRG GTIGRGGAPA
610 620 630 640 650
HAALLSQPPK SLKGGLRVTE QGEMIRFKLG LPEVAVNSFN MYASAILEAN
660 670 680 690 700
LLPPPEPKNE WRALMDILSE ISCNAYRKVV RGEPDFVPYF RQATPELELG
710 720 730 740 750
KLPLGSRPAK RNPTGGVESL RAIPWIFSWS QNRLILPAWL GAGEAIQIAI
760 770 780 790 800
NEGHQALLEE MCREWPFFST RLGMLEMVYT KCSVSIACHY DERLVEPTLR
810 820 830 840 850
PLGEKLRAQL QQDIKVVLNV ENNENLMQSD PWGQESIRLR NIYIEPLNML
860 870 880
QAELLYRTRQ SELPAPELEE ALMVTIAGIA AGMRNTG
Length:887
Mass (Da):99,644
Last modified:June 16, 2009 - v1
Checksum:i8CE06221BA3F28EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP06862.1.
RefSeqiWP_001883997.1. NC_012578.1.
YP_002811313.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP06862; ACP06862; VCM66_2566.
KEGGivcm:VCM66_2566.
PATRICi20068854. VBIVibCho108967_2445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP06862.1.
RefSeqiWP_001883997.1. NC_012578.1.
YP_002811313.1. NC_012578.1.

3D structure databases

ProteinModelPortaliC3LRV7.
SMRiC3LRV7. Positions 15-887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi579112.VCM66_2566.

Proteomic databases

PRIDEiC3LRV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP06862; ACP06862; VCM66_2566.
KEGGivcm:VCM66_2566.
PATRICi20068854. VBIVibCho108967_2445.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-2651-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2Imported.

Entry informationi

Entry nameiC3LRV7_VIBCM
AccessioniPrimary (citable) accession number: C3LRV7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 29, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.